Иммунная реконституция после трансплантации гемопоэтических стволовых клеток: современное состояние проблемы

Известно, что иммунная реконституция — многокомпонентный процесс, от которого зависит выживаемость и качество жизни пациентов после аллогенной трансплантации гемопоэтических стволовых клеток. Для оптимального иммунного ответа необходимо своевременное восстановление всех субпопуляций иммунных клеток: в норме восстановление происходит неравномерно. Основными факторами, влияющими на восстановление Т-клеток, являются реакция «трансплантат против хозяина» (РТПХ) и иммуносупрессивное лечение.

В обзоре представлены данные об иммунном восстановлении как комплексном процессе, факторах, оказывающих влияние на процесс восстановления, а также особенности и сроки восстановления натуральных киллеров, цитотоксических Т-лимфоцитов, Т-хелперов, В-лимфоцитов.

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