Criteria for hygienic standarding in the air of the working area of aerosols of dry products containing whey proteins of cow’s milk

Abstract

The aim of the work was to substantiate the maximum concentration limit in the air of the working area (MCLawa) of dust of dry products containing a complex of whey proteins of cow’s milk (WPM), according to the criterion of their leading harmful effect on the body. In experiments with subchronic inhalation intake into the body of white rats, it was found that WPM concentrations at the level of 3,0 and 1,0 mg/m3, which form pronounced dose-dependent allergic, general toxic and immunotoxic effects in the animal body, were active. The concentration at the level of 0,3 mg/m3 was defined as the threshold for the limiting indicator of the allergic effect, which was detected only in 40% of the experimental animals, and the concentration at the level of 0,1 mg/m3 was not effective. According to the criterion of the leading harmful allergic effect of WPM on the body, the value of MCLawa for aerosols of dry products containing whey proteins of cow’s milk, equal to 0,1 mg/m3 for protein marked «allergen», was substantiated.