Major indicators of insulin resistance in risk assessement of diabetes mellitus development

Abstract

To study clinical and laboratory indicators for algorithm design of early detection of insulin resistance and diabetes mellitus type 2 (DM 2). The study was conducted within 140 people of working age with body mass excess or obesity. The risk of the development of insulin resistance increases with the preperitoneal fat thickness (b=1,46) (ехр (b)=4,29 (1,54÷1,90), р=0,005): when the amount of preperitoneal fat more than 1,50 cm a relative risk (RR) of insulin resistance (IR) formation was 5,60 (2,48÷37,11). The risk of the development of IR with the triglycerides level more than 1,75 mmol/L was 2,86 (1,03÷7,91). The risk of the development of diabetes mellitus type 2 was significantly increased with age (b=0,11; ехр (b)=1,12 (1,01÷1,23), р<0,03). RR of diabetes mellitus type 2 within patients over the age of 37,74 years was1,52 (1,09÷15,39).The most significant observed risk factors of insulin resistance are the following: class I obesity within men, the thickness of preperitoneal adipose tissue more than 1,50 cm and triglyceride level more than 1,75 mmol/l. When there are no signs of insulin resistance, the age over 37,74 years within men and women.