A case of selective immunoglobulin A deficiency associated with Crohn's disease
https://doi.org/10.58708/2074-2088.2025-4(36)-103-108
Abstract
Selective immunoglobulin A (IgA) deficiency is considered the most common primary immunodeficiency. A specific genetic defect leading to this disease has not yet been identified. The true frequency of selective IgA deficiency in the population is unknown, as it is often asymptomatic and is a random laboratory finding. This immunodeficiency can manifest as respiratory tract infections, gastrointestinal tract infections, allergic disorders, and autoimmune diseases. According to the literature, patients with autoimmune disorders who have selective IgA deficiency have more severe and aggressive disease courses with a poorer prognosis. The clinical example of a combination of selective IgA deficiency and Crohn's disease demonstrates that patients with primary immunodeficiencies may not be aware of their condition for a long time. The article presents a case of Crohn's disease in a patient with selective immunoglobulin A deficiency, which was detected in early childhood.
About the Authors
E. S. Tikhonova
ГУ «РНПЦ радиационной медицины и экологии человека»
Belarus
Belarus
T. E. Gavrilenko
ГУ «РНПЦ радиационной медицины и экологии человека»
Belarus
Belarus
E. V. Rodina
ГУ «РНПЦ радиационной медицины и экологии человека»
Belarus
Belarus
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Review
For citations:
Tikhonova E.S., Gavrilenko T.E., Rodina E.V. A case of selective immunoglobulin A deficiency associated with Crohn's disease. Medical and Biological Problems of Life Activity. 2025;(4):103-108. (In Russ.) https://doi.org/10.58708/2074-2088.2025-4(36)-103-108
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