Toxic complications of chemotherapy for acute lymphoblastic leukemia in children according to the ALL-MB-2008 protocol
https://doi.org/10.58708/2074-2088.2025-4(36)-59-64
Abstract
Despite advances in the treatment of acute lymphoblastic leukemia in children, the toxicity of chemotherapy remains an open question and requires further analysis and practical solutions to reduce the incidence and severity of complications. An analysis of the structure and frequency of toxic complications of polychemotherapy under the ALL-MB-2008 program was conducted in 41 children. Hematological toxicity, infectious toxicity, and hepatotoxicity were observed in 100% of patients throughout the entire treatment period. Toxic complications developed statistically significantly more frequently during the induction and consolidation therapy stages compared to maintenance therapy. Adequate supportive therapy can mitigate toxic complications and reduce mortality in pediatric patients with acute lymphoblastic leukemia.
About the Authors
A. Demidenko
ГУ «РНПЦ радиационной медицины и экологии человека»
Belarus
Belarus
N. Klimkovich
УО «Белорусский государственный медицинский университет»
Belarus
Belarus
I. Romashevskaya
ГУ «РНПЦ радиационной медицины и экологии человека»
Belarus
Belarus
S. Khoduleva
УО «Гомельский государственный медицинский университет»
Belarus
Belarus
E. Mitsura
ГУ «РНПЦ радиационной медицины и экологии человека»
Belarus
Belarus
E. Borisova
ГУ «РНПЦ радиационной медицины и экологии человека»
Belarus
Belarus
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Review
For citations:
Demidenko A., Klimkovich N., Romashevskaya I., Khoduleva S., Mitsura E., Borisova E. Toxic complications of chemotherapy for acute lymphoblastic leukemia in children according to the ALL-MB-2008 protocol. Medical and Biological Problems of Life Activity. 2025;(4):59-64. (In Russ.) https://doi.org/10.58708/2074-2088.2025-4(36)-59-64
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