Immune reconstitution after hematopoietic stem cell transplantation: current state of the problem
https://doi.org/10.58708/2074-2088.2025-4(36)-16-21
Abstract
It is known that immune reconstitution is a multicomponent process that determines the survival and quality of life of patients after allogeneic hematopoietic stem cell transplantation. For an optimal immune response, it is necessary to restore all subpopulations of immune cells in a timely manner; normally, restoration occurs unevenly. The main factors influencing T-cell restoration are GVHD and immunosuppressive treatment.
The review presents data on immune restoration as a complex process, factors influencing the restoration process. Features and timing of restoration of natural killers, cytotoxic T-lymphocytes, T-helpers, B-lymphocytes.
About the Authors
L. V. Zherko
ГУ «РНПЦ детской онкологии, гематологии и иммунологии»
Belarus
Belarus
M. V. Belevtsev
ГУ «РНПЦ детской онкологии, гематологии и иммунологии»
Belarus
Belarus
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Review
For citations:
Zherko L.V., Belevtsev M.V. Immune reconstitution after hematopoietic stem cell transplantation: current state of the problem. Medical and Biological Problems of Life Activity. 2025;(4):16-21. (In Russ.) https://doi.org/10.58708/2074-2088.2025-4(36)-16-21
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