Gene polymorphism influence of the IL-1 and IL-4I in the development of chronic gastritis and gastric cancer

Abstract

When studying the relationship of polymorphism of genes IL-1 and IL-4 with chronic gastritis and gastric cancer we established the following regional particularities: If the patient has genotype 1/1 IL-1RN the risk of stomach cancer increases 2,2 times (p=0,003, OR=2,21, 95% CI 1,29-3,76); CT genotype IL-4 in C-33T 21 times; The presence of genotype 2/2 IL- 1RN increases the risk of chronic gastritis moderate or high activity of 2,3 times (p=0,021, OR=2,37, 95% CI 1,12 -5,02); If the patient has CT genotype IL-1? C-511T and genotype 2/2 IL-1 RN it increases the risk of infection having oncogenic potential сagA H. pylori strains in 2,2 times (p=0,005, OR=2,21, 95% CI 1,29-3,76) (p=0,034, OR=2,2, 95% CI 1,05-4,62). Data carriers of polymorphic loci for early detection of adverse disease require dispensary observation and inspection mandatory.