Evans syndrome in the practice of a pediatric hematologist
E. F. Mitsura,
E. S. Tihonova,
I. P. Romashevskaya,
S. A. Khoduleva,
A. N. Demidenko,
E. V. Borisova https://doi.org/10.58708/2074-2088.2026-1(37)-112-116
Abstract
The article presents information about Evans syndrome (ES), which is a rare disease with a combination of autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia (ITP), occurring in both children and adults. More than 70% of pediatric patients with ES have a predisposing immune defect, which requires a number of laboratory and instrumental studies, as well as molecular genetic tests to clarify the nature of the disease. Literature data on modern approaches to the diagnosis and treatment of this pathology are presented. Two cases of ES manifested in childhood from the authors’ clinical practice are presented. Both patients were consecutively diagnosed with AIHA and then ITP, concomitant diseases allowed us to assume, and subsequently reliably confirm, the presence of primary immunodeficiency in these patients. The effectiveness of treatment with glucocorticosteroids, intravenous immunoglobulin, mycophenolate mofetil is discussed.
About the Authors
E. F. Mitsura
ГУ «Республиканский научно-практический центр радиационной медицины и экологии человека»
Belarus
Belarus
E. S. Tihonova
ГУ «Республиканский научно-практический центр радиационной медицины и экологии человека»
Belarus
Belarus
I. P. Romashevskaya
ГУ «Республиканский научно-практический центр радиационной медицины и экологии человека»
Belarus
Belarus
S. A. Khoduleva
УО «Гомельский государственный медицинский университет»
Belarus
Belarus
A. N. Demidenko
ГУ «Республиканский научно-практический центр радиационной медицины и экологии человека»
Belarus
Belarus
E. V. Borisova
ГУ «Республиканский научно-практический центр радиационной медицины и экологии человека»
Belarus
Belarus
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Review
For citations:
Mitsura E.F., Tihonova E.S., Romashevskaya I.P., Khoduleva S.A., Demidenko A.N., Borisova E.V. Evans syndrome in the practice of a pediatric hematologist. Medical and Biological Problems of Life Activity. 2026;(1):112-116. (In Russ.) https://doi.org/10.58708/2074-2088.2026-1(37)-112-116
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