Risk factors for thrombotic complications in patients with Polycythemia Vera

Analysis of the relationship between clinical and laboratory parameters and the development of thrombotic complications during the period after diagnosis in a group of 194 patients with Polycythemia Vera (PV) confirmed the effectiveness of using a risk stratification system based on the presence of thrombotic events in the anamnesis and age over 60 years for predicting the risk of thrombosis (OR=3,6 [95% CI (1,6 and 8,0)], p=0,0008). Methods for additionally assessing the risk of arterial and venous thrombosis were proposed. Clarification of the risk of arterial thrombosis is based on determining such factor as the presence of coronary heart disease in the anamnesis (OR=5,2 [95% CI (1,8–14,8)]). An additional assessment of the risk of venous thrombosis is based on determining the presence of varicose veins of the lower extremities in the anamnesis (OR = 3,3 [95% CI (1,3–8,3)]) and a platelet count of more than 600×109 /l when diagnosing PV (OR = 3,2 [95% CI (1,1–9,7)]).

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