NEW FEATURES OF LABORATORY ASSESSMENT OF THE RISK OF TUMOR PROGRESSION IN OVARIAN CANCER
Abstract
This article provides information about newly discovered patterns of blood concentrations of tumor markers (HE4, LPA), proinflammatory cytokines (IL-8, TNF-?) and p55 soluble receptor in ovarian cancer patients. The study comprised 101 ovarian cancer patients and 30 clinically healthy women. Nonparametric statistical methods were used to analyze the content of all the studied indices with respect to tumor spread and basic clinical and morphological characteristics of the tumor. Their diagnostic value for preoperative risk assessment of ovarian cancer progression was determined. The most informative laboratory tests (HE4 and p55) were identified and a method of assessing the risk of tumor progression was developed, which allows to assess the risk of tumor progression preoperatively with a sensitivity, specificity and accuracy of 82.0%, 79.0% and 80.5% respectively.
About the Authors
O. V. Gotko
ГУ "РНПЦ онкологии и медицинской радиологии им. Н.Н. Александрова"
Russian Federation
Russian Federation
L. A. Derzhavets
ГУ "РНПЦ онкологии и медицинской радиологии им. Н.Н. Александрова"
Russian Federation
Russian Federation
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Review
For citations:
Gotko O.V., Derzhavets L.A. NEW FEATURES OF LABORATORY ASSESSMENT OF THE RISK OF TUMOR PROGRESSION IN OVARIAN CANCER. Medical and Biological Problems of Life Activity. 2016;(2):116-123. (In Russ.)
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