CLINICO-MORPHOLOGICAL FEATURES OF BREAST CANCER IN PATIENTS WITH GERMLINE BRCA1, BRCA2 AND CHEK2 MUTATIONS

Abstract

There has been performed the analysis of the clinico-morphological characteristics of breast cancer in 849 patients, including groups with mutations of the BRCA1, BRCA2 and CHEK2 genes. There has been performed the comparison of the groups with each other and with the group without the mutation. Spread tumors and tumors with higher clinical stage have been more common and tumors with negative estrogen receptor status and double- negative receptor status have been less common for patients with CHEK2 mutations than patients with BRCA1 mutations. The three times greater frequency of the presence of breast cancer and/or ovarian cancer in family history has been difference between the subgroups of patients with a 5382insC mutation and the subgroups with 300T> G, 4153delA, 185delAG mutations of the BRCA1.