Effect of chronic X-ray irradiation in low doses on the thoracic region in an experiment
https://doi.org/10.58708/2074-2088.2023-2(30)-17-22
Abstract
The effect of repeated low dose irradiation of the thoracic region of laboratory mice of the C57Bl/6 line on the general condition of laboratory animals and the condition of their lungs was studied. It has been shown that repeated local irradiation of the thoracic region of mice at a dose of 150 mGy (the total radiation dose was 1050 mGy) does not cause significant changes in the general condition of the animals, morphofunctional changes in the lungs of mice, but at the same time the level of apoptotic cells in the mixed population of lung cells increases to an aver -age of 6,7%, and also increases the level of pro-inflammatory cytokines IL-1 and TNFα in lung tissue homogenates, compared to the control, which indicates activation of innate immunity in irradiated tissue in response to repeated low-dose irradiation.
About the Authors
N. N. Veialkina
Институт радиобиологии НАН Беларуси; УО «Гомельский государственный медицинский университет»
Belarus
Belarus
L. A. Belaia
УО «Гомельский государственный медицинский университет»
Belarus
Belarus
O. S. Aksenenko
ГУ «Институт радиобиологии» НАН Беларуси
Belarus
Belarus
A. E. Suslenkova
ГУ «Институт радиобиологии» НАН Беларуси
Belarus
Belarus
E. A. Medvedeva
ГУ «Институт радиобиологии» НАН Беларуси
Belarus
Belarus
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Review
For citations:
Veialkina N.N., Belaia L.A., Aksenenko O.S., Suslenkova A.E., Medvedeva E.A. Effect of chronic X-ray irradiation in low doses on the thoracic region in an experiment. Medical and Biological Problems of Life Activity. 2023;(2):17-22. (In Russ.) https://doi.org/10.58708/2074-2088.2023-2(30)-17-22
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