Prolonged SARS-CoV-2 shedding at COVID-19 infection in patients with oncohematological diseases
Abstract
Patients with oncological and oncohematological diseases, after transplantation of solid organs or bone marrow, frequently suffer from severe COVID-19 infection, which is often fatal. The study involved 36 patients with various oncohematological diseases and confirmed COVID-19 infection. Verification of the infectious process was performed by real-time PCR with detection of the RNA of the virus from the oropharynx and nasopharynx within the first two days from the onset of symptoms of COVID-19 infection. The control group consisted of 24 patients with confirmed COVID-19 infection by PCR without oncohematological pathology. The duration of viral SARS-CoV-2 shedding (positive PCR analysis of naso / oropharyngeal swab) in patients with hematological diseases and COVID-19 infections, regardless of clinical symptoms, ranged from 11 to 59 days (median 31 days, interquartile range 25-38), and in the control group - from 9 to 26 days (median 14 days, interquartile range 11-18).In most patients with oncohematological diseases, there is a prolonged shedding of SARS-CoV-2 virus RNA during COVID-19 infection, confirmed by real-time PCR (naso/oropharyngeal swab).
About the Authors
M. M. Schepet'ko
ГУ «Минский НПЦ хирургии, трансплантологии и гематологии»
Russian Federation
Russian Federation
I. O. Stoma
УО «Гомельский государственный медицинский университет»
Russian Federation
Russian Federation
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Review
For citations:
Schepet'ko M.M., Stoma I.O. Prolonged SARS-CoV-2 shedding at COVID-19 infection in patients with oncohematological diseases. Medical and Biological Problems of Life Activity. 2021;(1):151-156. (In Russ.)
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