Features of expression of receptors of early and late activation of T-lymphocytes in patients after kidney transplantation

Abstract

We have examined a group of 175 recipients who underwent kidney transplantation. Patients were divided into groups: group 1 with satisfactory graft function on the 360th day after the transplantation, group 2 with chronic graft dysfunction, transplantectomy, and death during the first year after transplantation. We determined CD3+CD38+, CD3+CD8+CD38+, CD3+CD4+CD38+, CD3+CD69+, CD3+CD8+CD69+, CD3+CD4+CD69+, CD3+HLA-DR+, CD3+CD8+HLA-DR+ and CD3+CD4+HLA-DR+ on the 90th, 180th and 360th post-transplant days. The level of CD38+ cytotoxic T-lymphocytes in both groups was significantly lower than in the comparison group, while in the KRT 1 group the level of T-helpers was lower the reference values. One year after kidney transplantation, the number of CD3+CD8+CD69+ prevailed in the KRT 2 group, and CD3+CD4+CD69+ in the KRT 1 group. The number of T-lymphocytes expressing the HLA-DR receptor after 180 days prevailed in the KRT 1 and KRT 2 groups relative to the comparison group. However, the level of CD3+CD4+HLA-DR+ prevailed in the KRT 1 group, and CD3+CD8+HLA-DR+ in the KRT 2 group relative to CG by the end of the first year of follow-up. The obtained data can be applied in the case of necessity of correcting immunosuppressive therapy in the late post-transplant period.