The role of genetic polymorphism in the development of myocardial infarction in men from the Republic of Belaurs
Abstract
The article presents the results of molecular genetic analysis of 19 polymorphic variants in the genes of proteins responsible for coagulation (F1, F2, F5, F11, F13, FGG, GP6 and PAI- 1), regulation of vascular tone (eNOS, HIF1A, BDKRB2, MTHFR, VEGF and ACE) and lipid metabolism (LDLR and APOE) among men with myocardial infarction (MI) from the Republic of Belarus. The analysis of the frequency of prevalence of risk-associated genotypes with MI, depending on the age of patients. It has been shown that every second patient (47,6% of patients in this study) with MI has six or more risk-associated genotypes, for 7,2% of the examined patients with MI there are ten or more genetic risk factors.
About the Authors
A. G. Bulgak
РНПЦ «Кардиология» МЗ РБ
Russian Federation
Russian Federation
I. B. Mosse
Институт генетики и цитологии НАН Беларуси
Russian Federation
Russian Federation
O. V. Zotova
РНПЦ «Кардиология» МЗ РБ
Russian Federation
Russian Federation
T. S. Koroleva
РНПЦ «Кардиология» МЗ РБ
Russian Federation
Russian Federation
N. V. Nikolaeva
УО «Гомельский государственный медицинский университет»
Russian Federation
Russian Federation
A. L. Gonchar
Институт генетики и цитологии НАН Беларуси
Russian Federation
Russian Federation
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Review
For citations:
Bulgak A.G., Mosse I.B., Zotova O.V., Koroleva T.S., Nikolaeva N.V., Gonchar A.L. The role of genetic polymorphism in the development of myocardial infarction in men from the Republic of Belaurs. Medical and Biological Problems of Life Activity. 2021;(1):102-112. (In Russ.)
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