Method for predicting the development of subclinical Cushing’s syndrome in patients with adrenal incidentalomas

Abstract

The article presents a comparative analysis of laboratory criteria for patients with adrenal incidentalomas. Based on the data of statistical analysis, additional criteria were identified, the presence of which indicates the degree of risk of developing subclinical Cushing’s syndrome within 3-5 years. The use of additional diagnostic criteria made it possible to assess the progression of target organ damage in patients in whom the hormonal activity of a benign adrenal neoplasm was not confirmed during the initial examination. To systematize and rationalize the examination of patients with adrenal incidentaloma, a diagnostic algorithm has been developed. The autonomous hypersecretion of cortisol by the formation of the adrenal gland is determined. After additional examination, patients are distributed to one of the following groups: 1) hormonally inactive adrenal formation/group of low risk of SCS development; 2) patients with SCS/high risk of developing SCS. Treatment tactics are formed individually depending on the age and severity of the comorbidity.