Clinical and laboratory characteristics of patients with subclinical Cushing’s syndrome
Abstract
This article presents a comparative analysis of clinical and laboratory criteria of 37 patients with confirmed subclinical Cushing’s syndrome (SCS). Patients with SCS more frequently had underlying diagnoses: arterial hypertension (AH), chronic heart failure (CHF), type 2 diabetes mellitus (DM), osteopenia compared with the control group (CG). There were no significant differences in the clinical assessment of lipid metabolism. The sizes of hormonally inactive formations of the adrenal glands are significantly smaller (about 2 cm) than the ones in patients with adenomas. Cortisol level at 8:00 after the overnight dexamethasone supression test (overnight DST) in patients with SCS was significantly higher and always exceeded 138 nmol/l. Cortisol concentration in blood at 23.00 in SCS patients significantly exceeded normal values, which confirms the circadian dysregulation of cortisol secretion. A comparative analysis of daily cortisol level in the urine showed a significant increase in the concentration of the latter in patients with SCS. A comprehensive assessment of the above-mentioned clinical and laboratory criteria allows us to identify SCS and choose a sustainable treatment course further on.
About the Authors
A. V. Velichko
ГУ «РНПЦ радиационной медицины и экологии человека»
Russian Federation
Russian Federation
E. M. Bredihin
Независимая государственная провинциальная больница
Russian Federation
Russian Federation
A. A. Chulkov
ГУ «РНПЦ радиационной медицины и экологии человека»
Russian Federation
Russian Federation
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Review
For citations:
Velichko A.V., Bredihin E.M., Chulkov A.A. Clinical and laboratory characteristics of patients with subclinical Cushing’s syndrome. Medical and Biological Problems of Life Activity. 2022;(1):62-68. (In Russ.)
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