The assessment of the prevalence of hyperprolactinemia and parameters associated with changes in the level of prolactin in chronic kidney disease
Abstract
The development of chronic kidney disease (CKD) is associated with multiple hormonal disorders, which are caused by disorders of their secretion and clearance. The prevalence of hyperprolactinemia was assessed in 67 patients with various stages of CKD. It has been proven that the prevalence of hyperprolactinemia increases with a decrease in the estimated glomerular filtration rate (eGFR) and reaches a specific weight of 64,3% in patients with stage 5 CKD. The cut off value of eGFR MDRD (cut off) was determined less than 27 ml / min, which predicts the development of hyperprolactinemia with a sensitivity of 66,7% and a specificity of 76,1% (AUC = 0,671) (p<0,05). The revealed laboratory-instrumental dependences of hyperprolactinemia are functionally complex and require programmatic analysis. In the clinical picture, galactorrhea was observed only in two patients (one woman from group 1 (4,8%) and group 2 (2,2%) (p = 0,774).
About the Authors
Y. A. Volchek
УО «Белорусский государственный медицинский университет», г. Минск, Беларусь
Russian Federation
Russian Federation
N. V. Karlovich
ГУ «РЦ медицинской реабилитации и бальнеолечения», г. Минск, Беларусь
Russian Federation
Russian Federation
A. G. Sazonova
ГУ «РЦ медицинской реабилитации и бальнеолечения», г. Минск, Беларусь
Russian Federation
Russian Federation
T. V. Mokhort
УО «Белорусский государственный медицинский университет», г. Минск, Беларусь
Russian Federation
Russian Federation
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Review
For citations:
Volchek Y.A., Karlovich N.V., Sazonova A.G., Mokhort T.V. The assessment of the prevalence of hyperprolactinemia and parameters associated with changes in the level of prolactin in chronic kidney disease. Medical and Biological Problems of Life Activity. 2020;(2):72-81. (In Russ.)
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