Effect of single irradiation on the formation of tumors in the lungs of Af mouse

Abstract

At the present time, there is more and more evidence about the significance of the role of genetic predisposition for the development of lung tumors in response to influence of carcinogens factors. The aim of this research was to study age-related radiation-induced carcinogenesis in lungs of mice. In experiments, the mice were single-time exposed to the doses of 1 Gy and 3 Gy from a 137Cs source. After 6 or 6 moth, we analyzed the frequency of tumor formations in the lungs of mice and studied the level of cell deaths in their peripheral blood lymphocytes. The animals exposed to gamma-radiation manifested a significant growth in the frequency of tumor formations as against the age-control groups. This parameter, however, was comparable with the frequency of tumors in older animals of the same line. The comparative analysis of apoptosis in the peripheral blood lymphocytes of the mice of the control group and the irradiated ones six months after their exposure to a dose of 3 Gy, showed a credible dependence between the level of cell deaths of lymphocytes and lung tumorigenesis. The findings of this research suggest that a single-time exposure of Af mice to the doses of 1 and 3 Gy contributes to the manifestation of genetically-predisposed formation of tumors in the lungs of animals at a younger age.