The part of Helicobacter pylori in formation of myxocyte gene instability of antral segment of stomach in patients with chronic gastritis reside at the territory affected by the accident consequences of Chernobyl nuclear power plant

Abstract

Degree of micronucleus incidence in gastric superficial epithelium myxocyte in infected and uninfected Helicobacter pylori of gastric mucosa research was conducted. Histopathological examination of micronucleus and Helicobacter pylori were conducted in gastric biopsy specimen of patients with chronic gastritis (according to ICD-10K29.3) of the group of persons that reside at radiation contaminated territory and of the group of persons that has no facts of radiation exposure in the history. Maximum degree of myxocyte with micronucleus was in persons that reside at radiation contaminated territory with Helicobacter pylori infected. The degree of micronucleus incidence in myxocyte of gastric mucosa in the group of patients from the contaminated territory was fivefold more than in patients with gastric mucosa uninfected (p<0,001). Thus, with high probability it's possible to submit, that Helicobacter pylori activate mutagenic effect of radiation factor.