HYSIOLOGICAL EVALUATION OF A GENETIC PREDISPOSITION TO HAZARDOUS OCCUPATION

The analysis of gene polymorphism of metabolism regulators of the employees performing special tasks for the Armed forces of the Republic of Belarus revealed interrelation of gene alleles ACTN3, TFAM, PPARA and PPARGC1A and successful adaptation to intensive physical activities in performing combat training tasks. There were detected some peculiarities of changes in the parameters of the circulatory system in performing combat training tasks connected with high physical activity of people with different genotypes of the considered candidate genes. We have established regulators of metabolism alleles of genes associated with high rates of physical endurance. The relevance of screening of the ACTN3 gene polymorphisms, TFAM, PPARA and PPARGC1A was proven in the conduct of military-professional selection for service in the units performing specific tasks connected with high physical activity.

полиморфизм генов, молекулярная генетика, выносливость, функциональные резервы, профессиональный отбор, экстремальные виды профессиональной деятельности, адаптация, толерантность к физической нагрузке, нейродинамические функции, gene polymorphism, molecular genetics, physical endurance, functional reserves, professional selection, hazardous occupation, adaptation, tolerance to exercise load, neurodynamic functions

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