Воспаление как движущая сила нейродегенерации. Основы персонифицированной диагностики и лечения (обзор литературы)

ЦНС интегрирует эфферентные сигналы соматической и вегетативной частей. При этом ЦНС получает информацию с периферии о воспалении и инфекции. Цитокины, хемокины и ассоциированные с повреждением растворимые медиаторы системного воспаления могут попасть в ЦНС через кровеносную и/или лимфатическую системы, проникнуть непосредственно через околожелудочковые структуры, посредством повышения проницаемости гематоэнцефалического барьера и нарушить здоровое функционирование нейронов и глии, приводя к нарушению гомеостаза мозга. Это может привести к дебюту нейродегенеративного заболевания или ухудшить его клинические симптомы. В данной публикации мы приводим современные международные научные данные, свидетельствующие о связи между нейродегенеративным процессом и иммунными нарушениями. Кроме указания на иммуноопосредованные пути нейродегенерации, приводятся новые потенциально значимые иммуномодулирующие мишени для разработки возможной эффективной терапии данной группы заболеваний.

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