The role N-acetylcysteine (nac) in the therapy of diseases characterized by oxidative stress (literature review)
https://doi.org/10.58708/2074-2088.2023-2(30)-6-16
Abstract
Oxidative stress is a ubiquitous cellular process that results in damage to various biological molecules and it is involved in the etiopathogenesis of many diseases. The sulfhydryl-containing tripeptide glutathione (GSH), which is synthesized and maintained in high concentrations in all cells, is a component of one of the defense mechanisms. N-acetylcysteine, a synthetic derivative of the endogenous amino acid L-cysteine and a precursor of GSH, has been used for several decades as a mucolytic and antidote for acetaminophen (paracetamol) poisoning. As a mucolytic, N-acetylcysteine breaks the disulfide bonds of highly cross-linked mucins, thereby reducing the viscosity of the mucus. As an antidote for acetaminophen poisoning, N-acetylcysteine restores the hepatic GSH pool depleted during drug detoxification. More recently, enhance knowledge of N-acetylcysteine’s mechanisms of action has expanded its clinical use. This publication presents an overview of the most relevant and recent data on the clinical use of N-acetylcysteine in transplantology, neurology and ophthalmology.
About the Authors
S. V. Zybleva
ГУ «РНПЦ радиационной медицины и экологии человека»
Belarus
Belarus
Yu. I. Rozhko
ГУ «РНПЦ радиационной медицины и экологии человека»
Belarus
Belarus
A. V. Zharikova
ГУ «РНПЦ радиационной медицины и экологии человека»
Belarus
Belarus
B. O. Kabeshev
ГУ «РНПЦ радиационной медицины и экологии человека»
Belarus
Belarus
S. L. Zyblev
ГУ «РНПЦ радиационной медицины и экологии человека»
Belarus
Belarus
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Review
For citations:
Zybleva S.V., Rozhko Yu.I., Zharikova A.V., Kabeshev B.O., Zyblev S.L. The role N-acetylcysteine (nac) in the therapy of diseases characterized by oxidative stress (literature review). Medical and Biological Problems of Life Activity. 2023;(2):6-16. (In Russ.) https://doi.org/10.58708/2074-2088.2023-2(30)-6-16
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