The effect of photodynamic therapy on histological structure of the liver and blood biochemical parameters in CCl4-induced hepatitis, as the stage of the development of the cirrhosis

Abstract

The article analyses the effects of photodynamic therapy with Photolon on histological structure of the liver and blood biochemical parameters in CCl₄-induced hepatitis, as an early stage of development of cirrhosis. The data suggests that the use of photodynamic therapy has a positive effect on the restoration of the morphological structure of liver tissue and its functional activity in toxic hepatitis.It is shown that using the proposed methodology has a regulating action and ensures optimization of processes parenchymal regeneration of the liver on the background of experimentally simulated toxic hepatitis as an early stage of the cirrhosis development.Changes in histological structure and biochemical parameters indicate the normalization of the functional state of hepatocytes. They are observed already after 7 days after treatment and persisted through the month.Thus, the use of photodynamic therapy photosensitizer Photolon for the treatment of toxic hepatitis, as the stage of development of liver cirrhosis, is an effective method.