The effect of photodynamic therapy on histological structure of the liver and blood biochemical parameters in CCl4-induced hepatitis, as the stage of the development of the cirrhosis
Abstract
The article analyses the effects of photodynamic therapy with Photolon on histological structure of the liver and blood biochemical parameters in CCl4-induced hepatitis, as an early stage of development of cirrhosis. The data suggests that the use of photodynamic therapy has a positive effect on the restoration of the morphological structure of liver tissue and its functional activity in toxic hepatitis.It is shown that using the proposed methodology has a regulating action and ensures optimization of processes parenchymal regeneration of the liver on the background of experimentally simulated toxic hepatitis as an early stage of the cirrhosis development.Changes in histological structure and biochemical parameters indicate the normalization of the functional state of hepatocytes. They are observed already after 7 days after treatment and persisted through the month.Thus, the use of photodynamic therapy photosensitizer Photolon for the treatment of toxic hepatitis, as the stage of development of liver cirrhosis, is an effective method.
About the Authors
E. V. Mahiliavets
УО «Гродненский государственный медицинский университет», г. Гродно, Беларусь
Russian Federation
Russian Federation
P. V. Garelik
УО «Гродненский государственный медицинский университет», г. Гродно, Беларусь
Russian Federation
Russian Federation
S. S. Anufrik
УО «Гродненский государственный университет им. Янки Купалы», г. Гродно, Беларусь
Russian Federation
Russian Federation
N. I. Prokopchik
УО «Гродненский государственный медицинский университет», г. Гродно, Беларусь
Russian Federation
Russian Federation
References
1. Altered expression of interleukin 6 and interleukin 10 as a result of photodynamic therapy in vivo / S.O. Gollnick [et al.] // Cancer Res. - 1997. - Vol. 57. - P. 3904-3909.
2. Decoding cell death signals in liver inflammation / C. Brenner [et al.] // J Hepatol. - 2013. - Vol. 59, N3. - P. 583-594.
3. Incidence and prevalence ofcirrhosisin the United Kingdom, 1992-2001: a general population-based study / K.M. Fleming [et al.] // J Hepatol.- 2008. - Vol. 49, N5. - P. 732- 738.
4. Korbelik, M. Photosensitizer distribution and photosensitized damage of tumor tissues / The fundamental bases of phototherapy / H. Hцnigsmann, G. Jori, A.R. Youngs. - Milan: OEMF spa, 1996. - P. 229-245.
5. Luedde, T. Cell death and cell death responses in liver disease: mechanisms and clinical relevance / T. Luedde, N. Kaplowitz, R.F. Schwabe // Gastroenterology. - 2014. - Vol. 147, N4. - P. 765-783.
6. Tsochatzis, E.A. Liver cirrhosis / Tsochatzis EA, Bosch J, Burroughs AK. // Lancet. - 2014. - Vol. 383, N9930. - P. 1749- 1761.
7. Zhou, W.C. Pathogenesisofli
Review
For citations:
Mahiliavets E.V., Garelik P.V., Anufrik S.S., Prokopchik N.I. The effect of photodynamic therapy on histological structure of the liver and blood biochemical parameters in CCl4-induced hepatitis, as the stage of the development of the cirrhosis. Medical and Biological Problems of Life Activity. 2015;(1):48-56. (In Russ.)
Views: 135
Email this article 