Evaluation of the content of circular DNA molecules T- and B-receptor (TREC / KREC) in newborns of different gestational ages
Abstract
In this study, the normal range for TREC and KREC in the peripheral blood of 58 healthy full-term infants was determined. The number of TREC copies was 3383-238848 copies (Q1- Q3), KREC 2729-236953 copies per 1 million leukocytes (Q1-Q3). The influence of the gestational age of 117 newborns born prematurely (22,5-37,8 weeks) on the number of these markers was studied. It was shown that the amount of both TREC and KREC increased with increasing gestational age. It was revealed that the weight of both full-term and premature newborns of different gestational maturity does not affect the number of TREC and KREC
About the Authors
E. A. Polyakova
ГУ «РНПЦ детской онкологии, гематологии и иммунологии»
Russian Federation
Russian Federation
D. V. Ostrousko
ГУ «РНПЦ «Мать и дитя»
Russian Federation
Russian Federation
M. V. Stegantseva
ГУ «РНПЦ детской онкологии, гематологии и иммунологии»
Russian Federation
Russian Federation
I. E. Guryanova
ГУ «РНПЦ детской онкологии, гематологии и иммунологии»
Russian Federation
Russian Federation
Y. V. Tsimokhava
ГУ «РНПЦ детской онкологии, гематологии и иммунологии»
Russian Federation
Russian Federation
M. V. Belevtsev
ГУ «РНПЦ детской онкологии, гематологии и иммунологии»
Russian Federation
Russian Federation
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Review
For citations:
Polyakova E.A., Ostrousko D.V., Stegantseva M.V., Guryanova I.E., Tsimokhava Y.V., Belevtsev M.V. Evaluation of the content of circular DNA molecules T- and B-receptor (TREC / KREC) in newborns of different gestational ages. Medical and Biological Problems of Life Activity. 2021;(1):135-142. (In Russ.)
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