Toxicologo-hygienic substantiation of safe production and use of microbial preparation «Corneplus»

Abstract

The bacterial strain Pseudomonas putida K-9 does not possess toxic and toxigenic properties in standard doses and concentrations, belongs to the IV hazard class and is qualified as an industrial strain of microorganisms. The microbial preparation «Korneplus» does not irritate the skin and mucous membranes, does not have skin-resorptive properties, has a pronounced sensitizing ability, belongs to the 2nd class of allergenic danger, when inhaled at a standard concentration for a month, it causes the induction of a pronounced allergizing effect by mixed anaphylactic, complement-dependent cytotoxic, immunocomplex and delayed cell-mediated types of allergic reactions, it exhibits weak antigenic ability to activate the bactericidal function of phagocytes and weak stimulating immunomodulatory properties in the absence of hemotoxic action. The measures of medical prevention and safety requirements when working in contact with the microbial preparation «Korneplus» are defined.