Antitumor efficacy of thermochemotherapy in vivo experiment
Abstract
The paper presents the findings of an experimental study of laboratory animals with ascitic ovarian tumor with the aim to assess the antitumor efficacy of chemotherapeutic agents in the whole-body hyperthermia setting. The evaluation of the integral factor (the area under kinetic tumor growth curve and tumor growth index) demonstrated statistically significant differences vs the control group for all the chemotherapeutic agents under study. The comparison between the groups applying the drugs with and without hyperthermia showed a statistically significant improvement of the outcomes when employing hyperthermia with ifosfamide (p=0,045), cyclophosphamide (p=0,007), carboplatin (p=0,005) and oxaliplatin (p=0,047), which is indicative of the enhancing hyperthermia impact on the antitumor effect of these drugs.
About the Authors
O. P. Sergeeva
ГУ «РНПЦ онкологии и медицинской радиологии им. Н.Н. Александрова»
Russian Federation
Russian Federation
N. A. Artemova
ГУ «РНПЦ онкологии и медицинской радиологии им. Н.Н. Александрова»
Russian Federation
Russian Federation
E. N. Alexandrova
ГУ «РНПЦ онкологии и медицинской радиологии им. Н.Н. Александрова»
Russian Federation
Russian Federation
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Review
For citations:
Sergeeva O.P., Artemova N.A., Alexandrova E.N. Antitumor efficacy of thermochemotherapy in vivo experiment. Medical and Biological Problems of Life Activity. 2021;(1):81-87. (In Russ.)
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