Role of genetic polymorphism and intergene interference in increased probability of the pathological game dependence development
Abstract
The article presents the results of molecular genetic analysis of 13 polymorphic variants of genes ESR1, AS3MT, PECR, NT5C2, BUB1B-PAK6, EPHX2, HIP1, MUC7, CACNA1C, CHRNA4, DGKI and PIK3C2A of patients suffering from pathological gambling addiction. The analysis of the frequency of prevalence of genotypes and alleles, as well as the analysis of intergenic interactions to determine their combined impact on the risk of developing pathological gambling addiction. The loci rs17504622, rs73229090 (EPHX2), and rs237238 (HIP1) were found
About the Authors
E. V. Snytkov
УО «МГЭИ им. А.Д. Сахарова» БГУ
Russian Federation
Russian Federation
V. N. Kipen
ГНУ «Институт генетики и цитологии НАН Беларуси»
Russian Federation
Russian Federation
S. B. Melnov
УО «МГЭИ им. А.Д. Сахарова» БГУ
Russian Federation
Russian Federation
References
1. American Psychiatric Association and Task Force on DSM-IV. Diagnostic and Statistical Manual of Mental Disorders. Fourth Edition. Washington // DC: American Psychiatric Association. - 1994.
2. The Victorian Gambling Study: A Longitudinal Study of Gambling and Health in Victoria 2008-2012 / R. Billi [et al.] // Victoria, VIC: Victorian Responsible Gambling Foundation. - 2014.
3. Intergenerational Childhood Maltreatment in Persons with DSM-IV Pathological Gambling and Their First-Degree Relatives / S.K. Shultz [et al.] // Journal of gambling studies, 2016. - V. 32 (3). - P. 877-887. doi: 10.1007/s10899-015-9588-0.
4. The association between compulsory school achievement and problem gambling among Swedish young people / F. Fröberg [et al.] // The Journal of adolescent health: official publication of the Society for Adolescent Medicine, 2015. - V. 56 (4). - P. 420-428. doi: 10.1016/j.jadohealth.2014.12.007.
5. Gambling and Substance Use: Co-occurrence among Adults in a Recent General Population Study in the United States / G. Barnes [et al.] // International gambling studies, 2015. - V. 15 (1). - P. 55-71. doi: 10.1080/14459795.2014.990396.
6. Risk Factors for Gambling Problems: An Analysis by Gender / N. Hing [et al.] // Journal of gambling studies, 2016. - V. 32 (2). - P. 511-534. doi: 10.1007/s10899-015-9548-8.
7. Ермолич, С.Я. Гэмблинг как форма аддиктивного поведения. / С.Я. Ермолич // Диалог: психологический и социально-педагогический журнал, 2013. - №8. (е1-е7). URL: http://elib.bspu.by/handle/doc/517.
8. Addiction-related genes in gambling disorders: new insights from parallel human and pre-clinical models / D.S. Lobo [et al.] // Molecular psychiatry, 2015. - V. 20 (8). - P. 1002-1010. doi: 10.1038/mp.2014.113.
9. Gender differences in genetic and environmental influences on gambling: results from a sample of twins from the National Longitudinal Study of Adolescent Health / K.M. Beaver [et al.] // Addiction, 2010. - V. 105 (3). - P. 536-542. doi: 10.1111/j.1360-0443.2009.02803.x.
10. Disordered gambling as defined by the Diagnostic and Statistical Manual of Mental Disorders and the South Oaks Gambling Screen: evidence for a common etiologic structure / W. Slutske [et al.] // Journal of abnormal psychology, 2011. - V. 120 (3). - P 743-751. doi: 10.1037/a0022879.
11. Slutske, W. A closer look at the evidence for sex differences in the genetic and environmental influences on gambling in the national longitudinal study of adolescent health: from disordered to ordered gambling / W. Slutske, L. Richmond-Rakerd // Addiction, 2014. - V. 109 (1). - P. 120-127. doi: 10.1111/add.12345.
12. Lorains, F. Prevalence of comorbid disorders in problem and pathological gambling: systematic review and meta-analysis of population surveys / F. Lorains, S. Cowlishaw, S. Thomas // Addiction, 2011. - V. 106 (3). - P. 490-498. doi: 10.1111/j.1360-0443.2010.03300.x.
13. The intergenerational transmission of problem gambling: The mediating role of parental psychopathology / N. Dowling [et al.] // Addictive behaviors, 2016. - V. 59. - P. 12-17. doi: 10.1016/j.addbeh.2016.03.002.
14. Association of Problem Gambling with Type of Gambling Among Italian General Population / M. Scalese [et al.] // Journal of gambling studies, 2016. - V. 32 (3). - P. 1017-1026. doi: 10.1007/s10899-015-9579-1.
15. Министерство по налогам и сборам Республики Беларусь [Электронный ресурс]. - Режим доступа: http://nalog.gov.by/ru/deyatelnost-v-sfere-igornogo-biznesa/. Дата доступа: 10.01.2021.
16. Sambrook, J., Russel, D. Molecular Cloning: A Laboratory Manual /j. Sambrook, D.Russel // Cold Spring Harbor: Cold Spring Harbor Lab. Press. /j. Sambrook, D.Russel. - 3rd ed. - New York, 2001. - Chapter 1. - P. 11-14.
17. Gene regulation and DNA damage in the ageing human brain / T. Lu [et al.] // Nature, 2004. - V. 429 (6994). - P. 883-891. doi: 10.1038/nature02661.
18. Genome-wide association analysis identifies 13 new risk loci for schizophrenia / S. Ripke [et al.] // Nature genetics, 2013. - V. 45 (10). - P. 1150-1159. doi: 10.1038/ng.2742.
19. CalPen (Calculator of Penetrance), a web-based tool to estimate penetrance in complex genetic disorders / A. Addepalli [et al.] // PloS one, 2020. - V. 15 (1). P. e1-e10. e0228156. doi: 10.1371/journal.pone.0228156.
20. Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors. / I. Mills [et al.] - The Journal of cell biology, 2005. - V. 170 (2). - P. 191-200. doi: 10.1083/jcb.200503106.
21. Exploration of a Polygenic Risk Score for Alcohol Consumption: A Longitudinal Analysis from the ALSPAC Cohort. / M. Taylor [et al.] - PloS one, 2016. - V. 11 (11). - e1-e15. doi: 10.1371/journal.pone.0167360. eCollection 2016.
Review
For citations:
Snytkov E.V., Kipen V.N., Melnov S.B. Role of genetic polymorphism and intergene interference in increased probability of the pathological game dependence development. Medical and Biological Problems of Life Activity. 2021;(1):72-80. (In Russ.)
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