Cytokine profile in kidney transplant recipients in the early postoperative period
Abstract
We have carried out a comparative analysis of the cytokine contentl in the peripheral blood of 41 patients with chronic kidney disease who underwent kidney transplantation at the RRCRM&HE. The level of interleukin 2, 1β, 6, 8 was determined before transplantation, 24 hours later and 3 days after transplantation. A significant increase in the IL-2 level was revealed already 24 hours after the transplantation with a slight decrease by the 3rd day, however, the indicator remained higher relative to the concentration in the control group. There was a significant increase in the IL-6 level in comparison with the control group already 24 hours after kidney transplantation, a high level of which persisted for 3 days, despite a slight decrease. There were no significant differences in relation to the IL-1β level in renal transplant recipients in comparison with the control group in the first three days of the postoperative period. However, an increase in the concentration of this cytokine was noted by the 3rd day after transplantation. A significant predominance of the IL-8 level in recipients compared with control groups was revealed only on the first day of the postoperative period. The study of the IL-1β, 2, 6, 8 profile and factors affecting their concentration in renal transplant recipients in the early postoperative period is promising for determining new possibilities for specific therapy in order to improve the results of renal allograft transplantation.
About the Authors
S. . Zyblev
ГУ «РНПЦ радиационной медицины и экологии человека»
Russian Federation
Russian Federation
S. . Zybleva
ГУ «РНПЦ радиационной медицины и экологии человека»
Russian Federation
Russian Federation
L. . Korotaeva
ГУ «РНПЦ радиационной медицины и экологии человека»
Russian Federation
Russian Federation
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Review
For citations:
Zyblev S., Zybleva S., Korotaeva L. Cytokine profile in kidney transplant recipients in the early postoperative period. Medical and Biological Problems of Life Activity. 2021;(2):105-110. (In Russ.)
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