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The experience of using remote radiation therapy of prostate cancer in the hypofractionation dose mode

Abstract

The article presents the modern possibilities of remote radiation therapy of locally advanced prostate cancer. The method of 3D conformal radiation therapy with modulation of the intensity of the radiation beam, with the addition of a simultaneous integrated boost in the hypofraction mode for the treatment of locally advanced prostate cancer, has been proposed.On the basis of the Gomel Regional Clinical Oncology Center, patients were treated using this technique. The results of their treatment are analyzed. Long-term treatment outcomes were evaluated in terms of overall observed survival and relapse-free survival.Assessment of toxicity resulting from RT was carried out according to RTOG / EORTC standards. The results of the study of treated patients indicate the effectiveness of the proposed methodology and its advantage.Radiation therapy in hypofractionation mode is well tolerated by patients and is not accompanied by an increase in the frequency and severity of radiation damage to normaltissues.The developed technique allowed to increase the 3-year, 5-year overall and relapse-free survival rates.

About the Author

E. V. Kushnerova
У «Гомельский областной клинический онкологический диспансер»
Russian Federation


References

1. GLOBOCAN 2018 [Electronic resource]. - Mode of access :https://www.uicc.org/new-global-cancer-data-globocan. - Date of access: 04.12.2018.

2. Статистика онкологических заболеваний в Республике Беларусь (2008-2017) / А.Е. Океанов [и др.]; под ред. О.Г. Суконко. - Минск: РНПЦ ОМР им. Н.Н. Александрова, 2018. - 284 с.

3. Modification and implementation of NCCN guidelines on prostate cancer in the Middle East and North Africa region / W.A. Hassen [et al.] //j.NatlComprCancNetw. - 2010. - V. 8, No.3. - P. 26-28.

4. Radical prostatectomy is radiation therapy and androgen-suppression therapy in high-risk prostate cancer / K. Westover [et al.] // BJU Int. - 2012. - V. 110 (8). - P. 1116-1121.

5. D delineation of prostate, rectum and bladder on MR images / N. Betrouni [et al.] // Computerized Medical Imaging and Graphics. - 2008. - Vol. 32. - P. 622-630.

6. Климанов, В.А. Радиобиологическое и дозиметрическое планирование лучевой терапии и радионуклидной терапии: учеб. пособие: в 2 ч. / В.А. Климанов. - Москва: ННИУ МИФИ, 2011. - Ч. 1. - 500 с.

7. Volumetric modulated arc therapy for delivery of prostateradiotherapy: comparison with intensity-modulated radiotherapyand three-dimensional conformal radiotherapy/ Palma David [et al.] // International Journal of Radiation Oncology Biol. Phys. - 2008. - Vol. 72, No. 4. - P. 996-100.

8. Wang, J.Z. How low is the α/β ratio for prostate cancer /j.Z. Wang, M. Guerrero, X.A. Li //International Journal of Radiation Oncology Biology Physics. - 2003. - Vol. 55, No. 1. - P. 194-203.


Review

For citations:


Kushnerova E.V. The experience of using remote radiation therapy of prostate cancer in the hypofractionation dose mode. Medical and Biological Problems of Life Activity. 2019;(2):99-104. (In Russ.)

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ISSN 2074-2088 (Print)