Gene polymorphism influence of the IL-1 and IL-4I in the development of chronic gastritis and gastric cancer
Abstract
When studying the relationship of polymorphism of genes IL-1 and IL-4 with chronic gastritis and gastric cancer we established the following regional particularities: If the patient has genotype 1/1 IL-1RN the risk of stomach cancer increases 2,2 times (p=0,003, OR=2,21, 95% CI 1,29-3,76); CT genotype IL-4 in C-33T 21 times; The presence of genotype 2/2 IL- 1RN increases the risk of chronic gastritis moderate or high activity of 2,3 times (p=0,021, OR=2,37, 95% CI 1,12 -5,02); If the patient has CT genotype IL-1? C-511T and genotype 2/2 IL-1 RN it increases the risk of infection having oncogenic potential сagA H. pylori strains in 2,2 times (p=0,005, OR=2,21, 95% CI 1,29-3,76) (p=0,034, OR=2,2, 95% CI 1,05-4,62). Data carriers of polymorphic loci for early detection of adverse disease require dispensary observation and inspection mandatory.
About the Authors
A. . Voropayeva
ГУ «РНПЦ радиационной медицины и экологии человека», г. Гомель, Беларусь
Russian Federation
Russian Federation
O. . Karpenko
ГУ «РНПЦ радиационной медицины и экологии человека», г. Гомель, Беларусь
Russian Federation
Russian Federation
A. . Silin
ГУ «РНПЦ радиационной медицины и экологии человека», г. Гомель, Беларусь
Russian Federation
Russian Federation
E. . Bredikhina
ГУ «РНПЦ радиационной медицины и экологии человека», г. Гомель, Беларусь
Russian Federation
Russian Federation
V. . Martinkov
ГУ «РНПЦ радиационной медицины и экологии человека», г. Гомель, Беларусь
Russian Federation
Russian Federation
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Review
For citations:
Voropayeva A., Karpenko O., Silin A., Bredikhina E., Martinkov V. Gene polymorphism influence of the IL-1 and IL-4I in the development of chronic gastritis and gastric cancer. Medical and Biological Problems of Life Activity. 2017;(1):123-127. (In Russ.)
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