Diagnosis of immune mechanism disorders in preterm infants using markers of T- and B-cell neogenesis (TREC and KREC) and subpopulations of T- and B-lymphocytes
Abstract
To establish the stages of diagnosis of immune mechanism disorders in preterm infants, a comprehensive clinical and laboratory examination of 120 infants born at Me=33,5 (29,5-35,0) weeks of gestation was performed, determining markers of T- and B-cell neogenesis (TREC/KREC) and subpopulations of T- and B-lymphocytes.The impaired immune mechanism in preterm infants was evidenced by a persistent decrease in peripheral blood lymphocytes ≤1.0×109/l after 4 days of life; reduced or undetectable levels of T- and B-cell neogenesis markers by 37 weeks postconceptional age; and reduced lymphocyte subpopulation scores.
About the Authors
E. A. Polyakova
ГУ «РНПЦ детской онкологии, гематологии и иммунологии»
Russian Federation
S. A. Beresten
ГУ «РНПЦ «Мать и дитя»
Russian Federation
M. V. Stegantseva
ГУ «РНПЦ детской онкологии, гематологии и иммунологии»
Russian Federation
A. S. Starovoitova
ГУ «РНПЦ «Мать и дитя»
Russian Federation
A. N. Kupchinskaya
ГУ «РНПЦ детской онкологии, гематологии и иммунологии»
Russian Federation
I. E. Guryanova
ГУ «РНПЦ детской онкологии, гематологии и иммунологии»
Russian Federation
S. M. Mezyan
ГУ «РНПЦ «Мать и дитя»
Russian Federation
M. V. Belevtsev
ГУ «РНПЦ детской онкологии, гематологии и иммунологии»
Russian Federation
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For citations:
Polyakova E.A.,
Beresten S.A.,
Stegantseva M.V.,
Starovoitova A.S.,
Kupchinskaya A.N.,
Guryanova I.E.,
Mezyan S.M.,
Belevtsev M.V.
Diagnosis of immune mechanism disorders in preterm infants using markers of T- and B-cell neogenesis (TREC and KREC) and subpopulations of T- and B-lymphocytes. Medical and Biological Problems of Life Activity. 2022;(2):93-98.
(In Russ.)
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