CONSTRUCTION OF COHORT OF PERSONS EXPOSED IN UTERO IN BELARUS FOLLOWING THE CHERNOBYL ACCIDENT
Abstract
The paper describes the methodology to construct a cohort of people exposed in utero in Belarus after the Chernobyl fallout, namely sources of information and methods of data collection, including information essential for individual dose reconstruction such as personal whereabouts, sources and type of food at the time of the radioactive fallout and after it. The paper presents current status of the cohort construction and some characteristics of the cohort, including internal and external doses to the thyroid from pre- and postnatal radiation exposure. The paper discusses perspectives of research on radiation-related risks of thyroid and non-thyroid cancers as well as of non-cancer thyroid diseases.
About the Authors
V. . Yauseyenka
ГУ "РНПЦ радиационной медицины и экологии человека"
Russian Federation
Russian Federation
V. . Drozdovitch
Национальный институт рака
Russian Federation
Russian Federation
E. . Ostroumova
Международное агентство по изучению рака
Russian Federation
Russian Federation
V. . Minenko
Институт ядерных проблем
Russian Federation
Russian Federation
M. . Hatch
Национальный институт рака
Russian Federation
Russian Federation
O. . Polyanskaya
ГУ "РНПЦ радиационной медицины и экологии человека"
Russian Federation
Russian Federation
A. . Brenner
Национальный институт рака
Russian Federation
Russian Federation
I. . Veyalkin
ГУ "РНПЦ радиационной медицины и экологии человека"
Russian Federation
Russian Federation
E. . Nadyrov
ГУ "РНПЦ радиационной медицины и экологии человека"
Russian Federation
Russian Federation
L. . Starostenko
ГУ "РНПЦ радиационной медицины и экологии человека"
Russian Federation
Russian Federation
A. . Rozhko
ГУ "РНПЦ радиационной медицины и экологии человека"
Russian Federation
Russian Federation
K. . Mabuchi
Национальный институт рака
Russian Federation
Russian Federation
References
1. Solid cancer incidence in atomic bomb survivors exposed in utero or as young children / D. Preston [et al.] // J Natl Cancer Inst. - 2008. - Vol. 100. - P. 428-436.
2. Cancer mortality among atomic bomb survivors exposed in utero or as young children / R. Delongchamp [et al.] // Radiat Res. - 1997. - Vol. 147. - P. 385-395.
3. Malignant disease in childhood and diagnostic irradiation in utero / D. Giles [et al.] // Lancet. - 1956. - Vol. 271. - P. 447.
4. Doll, R. Risk of childhood cancer from fetal irradiation / R. Doll, R. Wakeford // Br J Radiol. - 1997. - Vol. 70. - P. 130-139.
5. Cancer mortality following in utero exposure among offspring of female Mayak Worker Cohort members / S. Schonfeld [et al.] // Radiat Res. - 2012. - Vol. 178. - P. 160-165.
6. Ostroumova. E. Cancer mortality among Techa riverside residents (Southern Urals), chronically exposed to radiation during the prenatal period and in childhood. Proceedings of the 11th International Congress of the International Radiation Protection Association / E. Ostroumova, A. Akleyev // http://irpa11.irpa.net/pdfs/1b21.pdf Madrid. - 2004.
7. A screening study of thyroid cancer and other thyroid diseases among individuals exposed in utero to iodine-131 from Chernobyl fallout / M. Hatch [et al.] // J Clin Endocrinol Metab. - 2009. - Vol. 94. - P. 899-906.
8. A cohort study of thyroid cancer and other thyroid diseases after the chornobyl accident: thyroid cancer in Ukraine detected during first screening / M.D. Tronko [et al.] // J Natl Cancer Inst. - 2006. - Vol. 98. - P. 897-903.
9. Thyroid cancer risk in Belarus among children and adolescents exposed to radioiodine after the Chornobyl accident / L. Zablotska [et al.] // Br J Cancer. - 2011- Vol. 104. - P. 181-187.
10. I-131 dose-response for incident thyroid cancers in Ukraine related to the Chornobyl accident / A.V. Brenner [et al.] // Environ Health Perspect. - 2011. - Vol. 119. - P. 933- 939.
11. Subclinical hypothyroidism after radioiodine exposure: Ukrainian-American cohort study of thyroid cancer and other thyroid diseases after the Chornobyl accident (1998-2000) / E. Ostroumova [et al.] // Environ Health Perspect. - 2009. - Vol. 117. - P. 745- 750.
12. Measures of thyroid function among Belarusian children and adolescents exposed to iodine-131 from the accident at the Chernobyl nuclear plant / E. Ostroumova [et al.] // Environ Health Perspect. - 2013. - Vol. 121. - P. 865-871.
13. Proliferative activity of human thyroid cells in various age groups and its correlation with the risk of thyroid cancer after radiation exposure / A. Saad [et al.] // J Clin Endocrinol Metab. - 2006. - Vol. 9. - P. 2672-2677.
14. Expression of Na+/I- symporter and Pendred syndrome genes in trophoblast cells / J.M. Bidart [et al.] // J Clin Endocrinol Metab. - 2000. - Vol. 85. - P. 4367-4372.
15. Gorman, C. Radioiodine and pregnancy / C. Gorman // Thyroid. 1999. - Vol. 9. - P. 721-726.
16. International Commission on Radiological Protection. Doses to the embryo and fetus from intakes of radionuclides by the mother: ICRP Publication 88 / Ann ICRP. - 2001. - Vol. 31.
17. Thyroid dose estimates for a cohort of Belarusian children exposed to radiation from the Chernobyl accident / V. Drozdovitch [et al.] // Radiat Res. - 2013. - Vol. 179. - P. 597-609.
18. Chernobyl accident: Reconstruction of thyroid dose for inhabitants of the Republic of Belarus / Y.I. Gavrilin [et al.] //. Health Phys. - 1999. - Vol. 76. - P. 105-119.
19. Individual thyroid dose estimation for a case-control study of Chernobyl-related thyroid cancer among children of Belarus-Part II: Contribution from long-lived radionuclides and external radiation / V. Minenko [et al.] // Health Phys. - 2006. - Vol. 90. - P. 312-327.
20. International Commission on Radiological Protection. Conversion coefficient for use in radiological protection against external irradiation. ICRP Publication 74. //Ann. ICRP. - 1996. - Vol. 26(3).
21. Estimation of the thyroid doses for Ukrainian children exposed in utero after the Chornobyl accident / I. Likhtarov [et al.] //. Health Phys. - 2011. - Vol. 100. - P. 583-593.
Review
For citations:
Yauseyenka V., Drozdovitch V., Ostroumova E., Minenko V., Hatch M., Polyanskaya O., Brenner A., Veyalkin I., Nadyrov E., Starostenko L., Rozhko A., Mabuchi K. CONSTRUCTION OF COHORT OF PERSONS EXPOSED IN UTERO IN BELARUS FOLLOWING THE CHERNOBYL ACCIDENT. Medical and Biological Problems of Life Activity. 2016;(1):113-123. (In Russ.)
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