Formula for calculating oxidative stress index in patients with liver cirrhosis and acute blood loss

The chemistry of free radicals has not yet received the attention it deserves in medical research. It is generally accepted that free radicals are active forms of non-metals: chalcogenes, pnictogens, halogens. They enter into complex and multistage reactions with the biological membranes of cells, disrupting their functional activity and creating a general pathological state called oxidative stress. Today it is important to determine the presence and concentration of both intermediate metabolites of reactions and final metabolites of oxidation reactions in order to determine the severity (stages and depth of manifestations) of oxidative stress. The study of the concentrations of a number of products of pathobiochemical reactions in oxidative stress can be considered promising and scientifically justified. These parameters include total antioxidant capacity, reduced glutathione, total mercaptogroups, protein oxidation products, nitrate and nitrite ions, malonic dialdehyde, superoxide dismutase, catalase and glutathione reductase. The unification of the above parameters in the general pathogenesis of oxidative stress is a promising study to derive a mathematical formula for calculating the oxidative stress index in patients with cirrhosis and acute blood loss.

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