Preclinical stage of testing new wound dressings in an animal experiment: dynamics of wound healing and the levels of growth factors
https://doi.org/10.58708/2074-2088.2025-1(33)-79-88
Abstract
Treatment of patients with trophic disorders due to diabetes mellitus is an important medical and social problem, since decompensation and progression of the disease and its complications often lead to disability of patients. The presence of long-term non-healing trophic ulcers requires daily, often painful, dressings, which significantly reduces the quality of life of patients. Therefore, the development of composite hydrogel coatings of prolonged action will solve one of the most important problems of modern surgery. The article presents the results of a biochemical analysis of the blood of laboratory rats with the determination of the level of fibroblast growth factor-2 and endothelin-1 in dynamics against the background of the use of the developed hydrogel wound coatings of prolonged action. Based on the obtained data, the optimal composition of wound dressing for the treatment of trophic ulcers against the background of ischemia in diabetes mellitus was determined.
Keywords
wound dressings,
wound healing,
endothelin-1,
fibroblast growth factor,
diabetes mellitus,
trophic ulcer
УДК: 616-001.4-089-092.9:57.084
About the Authors
V. I. Silvistrovich
Gomel State Medical University Educational Institution
Belarus
Belarus
Gomel
A. A. Lyzikov
Bradford teaching hospital NHS Foundation Trus
United Kingdom
United Kingdom
Bradford
Yu. I. Yarets
State Institution "Russian Scientific Research Center for Radiation Medicine and Human Ecology"
Belarus
Belarus
Gomel
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For citations:
Silvistrovich V.I., Lyzikov A.A., Yarets Yu.I. Preclinical stage of testing new wound dressings in an animal experiment: dynamics of wound healing and the levels of growth factors. Medical and Biological Problems of Life Activity. 2025;(1):79-88. (In Russ.) https://doi.org/10.58708/2074-2088.2025-1(33)-79-88
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