medbioМедико-биологические проблемы жизнедеятельностиMedical and Biological Problems of Life Activity2074-2088Республиканский научно-практический центр радиационной медицины и экологии человекаmedbio-88Research ArticleОБЗОРЫ И ПРОБЛЕМНЫЕ СТАТЬИREVIEWS AND PROBLEM ARTICLESОстрый и хронический раневой процесс: патогенетические особенностиAcute and chronic wound healing: the peculiarities of pathogenesisЯрецЮ. И.YaretsY. .noemail@neicon.ruГУ "РНПЦ радиационной медицины и экологии человека"Russian Federation201602032023022134Copyright © Ярец Ю.И., 20232023Ярец Ю.И.Yarets Y...Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://medbio.ejournal.by/jour/article/view/88

В обзоре литературы изложены современные представления о течении нормального раневого процесса, соответствующего заживлению острой раны. Даны сведения об особенностях взаимодействий клеточных и гуморальных механизмов в различные фазы раневого заживления. Представлены патогенетические различия в течение заживления хронической раны, характеризующейся дефектом в цепи одной из фаз раневого процесса. Уделено внимание описанию патологического воспаления, представляющего собой разбалансированные реакции иммунной системы в ответ на длительную персистенцию бактерий-продуцентов биопленки и являющегося отличительной чертой хронических ран.

It is presented the modern aspects of normal wound healing as a characteristic of acute wound process in the review. The information about the interaction features of cellular and humoral defenses mechanisms in the different phases of wound healing is given. It is presented the differences in the pathogenesis of chronic wound healing characterized in the defects of the healing process stages. It is paid the attention of the prolonged pathological inflammation as unbalanced immune reactions in the response to the biofilm producers' bacteria persistence which is the distinguishing feature of chronic wound.

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The authors declare that there are no conflicts of interest present.