References

medbio

Медико-биологические проблемы жизнедеятельности

Medical and Biological Problems of Life Activity

2074-2088

Республиканский научно-практический центр радиационной медицины и экологии человека

10.58708/2074-2088.2026-3(39)-51-63

medbio-547

Research Article

КЛИНИЧЕСКАЯ МЕДИЦИНА

CLINICAL MEDICINE

Взаимосвязь расстройств взаимодействия «кишечник — мозг» и заболеваний печени

The Interplay Between Gut–Brain Interaction Disorders and Liver Diseases

https://orcid.org/0000-0001-7496-6164

Гавриленко

Д. И.

Haurylenka

D. I.

г. Гомель

propedeutic_id@mail.ru

Родина

Е. В.

Rodina

E. V.

г. Гомель

Rodinae2020@rambler.ru

Жарикова

А. В.

Zharikova

A. V.

г. Гомель

info@rcrm.by

ГУ «РНПЦ радиационной медицины и экологии человека»Christmas Island

2026

01112026

035163

2026

Гавриленко Д.И., Родина Е.В., Жарикова А.В.

Haurylenka D.I., Rodina E.V., Zharikova A.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://medbio.ejournal.by/jour/article/view/547

Расстройства взаимодействия оси «кишечник–мозг» (РВКМ) и заболевания печени метаболического генеза, включая их терминальную стадию, — цирроз печени (ЦП), включены в патогенетический континуум, в рамках которого каждый из компонентов может быть значимым драйвером прогрессирования. Ключевым звеном выступает системное низкоинтенсивное воспаление (low–grade inflammation), индуцированное портальной эндотоксемией и нейроиммунной дисрегуляцией. Цель обзора. Систематизировать современные данные о механизмах взаимосвязи, методах лечения РВКМ и заболеваний печени. В статье приводятся концепции восходящей (Bottom–Up) и нисходящей (Top–Down) модуляции сигналов, актуальные данные об изменениях микробиоты при РВКМ и заболеваниях печени. Особое внимание уделено возможностям диагностики и терапевтическим методам для целевого воздействия на значимые патофизиологические звенья. Заключение. Понимание роли взаимосвязи РВКМ и заболеваний печени аргументируют необходимость организации междисциплинарных команд, основной задачей которых является комплексная терапия РВКМ. Будущие исследования должны быть сфокусированы на определении биомаркеров нарушений профиля микробиоты, разработке фармакотерапевтического влияния на ключевой механизм прогрессирования — системное воспаление.

Disorders of the gut-brain interactions (DGBI) and metabolic liver diseases (MASLD/ MASH), including their end–stage cirrhosis, are included in a pathogenetic continuum, within which each component can be a significant driver of progression. A key link is systemic subclinical inflammation (low–grade inflammation) induced by portal endotoxemia and neuroimmune dysregulation. Objective. To systematize current data on the mechanisms of interactions and treatment methods for DGBI and liver diseases. The article presents the concepts of Bottom–Up and Top–Down signaling modulation, as well as current data on microbiota changes in DGBI and liver diseases. Particular attention is paid to diagnostic capabilities and therapeutic methods for targeting significant pathophysiological links. Conclusion. Understanding the role of the relationship between DGBI and liver disease underscores the need for interdisciplinary teams focused on comprehensive treatment of disorders of the gut–liver–brain axis. Future research should focus on identifying biomarkers of microbiota imbalances and developing pharmacotherapeutic interventions targeting the key mechanism of progression – systemic inflammation.

ось «кишечник — мозг»цирроз печенинизкоинтенсивное воспалениемикробиотапробиотики

gut-brain axiscirrhosislow-grade inflammationmicrobiotaprobiotics

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The authors declare that there are no conflicts of interest present.