medbioМедико-биологические проблемы жизнедеятельностиMedical and Biological Problems of Life Activity2074-2088Республиканский научно-практический центр радиационной медицины и экологии человека10.58708/2074-2088.2024-2(32)-15-22medbio-396Research ArticleОБЗОРЫ И ПРОБЛЕМНЫЕ СТАТЬИREVIEWS AND PROBLEM ARTICLESВоспаление как движущая сила нейродегенерации. Основы персонифицированной диагностики и лечения (обзор литературы)Inflammation as a driving force of neurodegeneration. Fundamentals of personalized diagnostics and treatmentВистЭ. В.VistE. V.

Ассистент кафедры неврологии и нейрохирургии

г. Минск

edgar.vist@mail.ruБойкоА. В.BoikaA. V.

Кандидат медицинских наук, доцент кафедры неврологии и нейрохирургии

г. Минск

AVBoika@yandex.byСелицкийМ. М.SialitskiM. M.

Кандидат медицинских наук, доцент кафедры неврологии и нейрохирургии

г. Минск

m_sialitski@tut.byИПКП кадров здравоохранения УО «Белорусский государственный медицинский университет»Belarus202420092024021522Copyright © Вист Э.В., Бойко А.В., Селицкий М.М., 20242024Вист Э.В., Бойко А.В., Селицкий М.М.Vist E.V., Boika A.V., Sialitski M.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://medbio.ejournal.by/jour/article/view/396

ЦНС интегрирует эфферентные сигналы соматической и вегетативной частей. При этом ЦНС получает информацию с периферии о воспалении и инфекции. Цитокины, хемокины и ассоциированные с повреждением растворимые медиаторы системного воспаления могут попасть в ЦНС через кровеносную и/или лимфатическую системы, проникнуть непосредственно через околожелудочковые структуры, посредством повышения проницаемости гематоэнцефалического барьера и нарушить здоровое функционирование нейронов и глии, приводя к нарушению гомеостаза мозга. Это может привести к дебюту нейродегенеративного заболевания или ухудшить его клинические симптомы. В данной публикации мы приводим современные международные научные данные, свидетельствующие о связи между нейродегенеративным процессом и иммунными нарушениями. Кроме указания на иммуноопосредованные пути нейродегенерации, приводятся новые потенциально значимые иммуномодулирующие мишени для разработки возможной эффективной терапии данной группы заболеваний.

The CNS integrates efferent signals from the somatic and autonomic parts. Also the CNS also receives information from the periphery about inflammation and infection. Cytokines, chemokines and damage-associated soluble mediators of systemic inflammation can also enter the CNS via the blood and/or lymphatic systems. At the same time these substances can penetrate directly through periventricular structures, as well as by increasing the permeability of the blood-brain barrier and disrupt the healthy functioning of neurons and glia, leading to a violation of brain homeostasis. This can lead to the onset of a neurodegenerative disease or worsen its clinical symptoms. In this publication, we present current international scientific data indicating a link between the neurodegenerative process and immune disorders. In addition to identifying immune-mediated pathways of neurodegeneration, new, potentially significant, immunomodulatory targets are presented for the development of possible effective therapy for this group of diseases.

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The authors declare that there are no conflicts of interest present.