medbioМедико-биологические проблемы жизнедеятельностиMedical and Biological Problems of Life Activity2074-2088Республиканский научно-практический центр радиационной медицины и экологии человека10.58708/2074-2088.2024-1(31)-6-15medbio-372Research ArticleОБЗОРЫ И ПРОБЛЕМНЫЕ СТАТЬИREVIEWS AND PROBLEM ARTICLESГладкомышечные опухоли с неопределенным злокачественным потенциалом (STUMP): современное состояние проблемыSmooth muscle tumors of uncertain malignant potential (STUMP): current state of the problemЗахаркоА. Ю.ZaharkoA. Yu.

г. Гомель

annazakharko@tut.byПодгорнаяА. С.PodgornayaA. S.

г. Гомель

МурашкоО. В.MurashkoO. V.

г. Гомель

ЖандаровМ. Ю.ZhandarovМ. Yu.

г. Гомель

РомбальскаяА. Р.RombalskayaA. R.

г. Минск

ГУ «РНПЦ радиационной медицины и экологии человека»BelarusУО «Белорусский государственный медицинский университет»Belarus20240509202401615Copyright © Захарко А.Ю., Подгорная А.С., Мурашко О.В., Жандаров М.Ю., Ромбальская А.Р., 20242024Захарко А.Ю., Подгорная А.С., Мурашко О.В., Жандаров М.Ю., Ромбальская А.Р.Zaharko A.Y., Podgornaya A.S., Murashko O.V., Zhandarov М.Y., Rombalskaya A.R.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://medbio.ejournal.by/jour/article/view/372

Наиболее распространенным типом опухолей матки являются гладкомышечные опухоли: доброкачественные лейомиомы, гладкомышечные опухоли неопределенного злокачественного потенциала (STUMP), саркомы. Частоту возникновения STUMP трудно оценить. Они составляют 1,3% всех злокачественных новообразований матки. Для подтверждения правильного диагноза STUMP необходимо тщательное гистопатологическое исследование из-за ненадежности предоперационных методов визуализации для дифференциации лейомиомы, STUMP и лейомиосаркомы. По сравнению с саркомами STUMP имеют лучший прогноз, но их биологический потенциал не определен, поскольку рецидивы, малигнизация и метастазы возможны много лет спустя. Учитывая редкость опухолей с неопределенным злокачественным потенциалом, малое число публикаций по их лечению, не существует клинических рекомендаций по тактике ведения и лечения пациентов с этой патологией. В статье рассмотрены современные данные по диагностике и дифференциальной диагностике гладкомышечных опухолей, тактике ведения, лечения, прогнозу пациентов со STUMP.

The most common type of uterine tumors are smooth muscle tumors: benign leiomyomas, smooth muscle tumors of uncertain malignant potential (STUMP), sarcomas. The incidence of STUMP is difficult to estimate. They account for 1,3% of all uterine malignancies. A thorough histopathological examination is necessary to confirm the correct diagnosis of STUMP due to the unreliability of preoperative imaging techniques for differentiating between leiomyoma, STUMP and leiomyosarcoma. Compared with sarcomas, STUMP have a better prognosis, but their biological potential is uncertain because recurrence, malignancy, and metastasis are possible many years later. Considering the rarity of tumors with uncertain malignant potential, the small number of publications on their treatment, there are no clinical recommendations for the management and treatment of patients with this pathology. The article reviews current data on the diagnosis and differential diagnosis of smooth muscle tumors, management tactics, treatment, and prognosis of patients with STUMP.

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The authors declare that there are no conflicts of interest present.