medbioМедико-биологические проблемы жизнедеятельностиMedical and Biological Problems of Life Activity2074-2088Республиканский научно-практический центр радиационной медицины и экологии человека10.58708/2074-2088.2024-1(31)-22-29medbio-361Research ArticleОБЗОРЫ И ПРОБЛЕМНЫЕ СТАТЬИREVIEWS AND PROBLEM ARTICLESФакторы прогрессирования аллергических заболеваний у детей (обзор литературы)Factors of allergic disease progression in children (literature review)ТихоноваЕ. С.TikhonovaE. S.

г. Гомель

ЗыблеваС. В.ZyblevaS. V.

г. Гомель

zyb-svetlana@yandex.ruМартинковВ. Н.MartinkovV. N.

г. Гомель

ГУ «РНПЦ радиационной медицины и экологии человека»Belarus202403062024012229Copyright © Тихонова Е.С., Зыблева С.В., Мартинков В.Н., 20242024Тихонова Е.С., Зыблева С.В., Мартинков В.Н.Tikhonova E.S., Zybleva S.V., Martinkov V.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://medbio.ejournal.by/jour/article/view/361

Развитие атопического дерматита в раннем возрасте и последующего аллергического ринита и астмы в более позднем известно как явление атопического марша. Несмотря на сложность и многообразие механизмов развития атопии, показано, что атопический дерматит и аллергические заболевания дыхательных путей имеют общий патогенез. Установлено, что прогрессирование от атопического дерматита до бронхиальной астмы и ринита связано со сложным взаимодействием генетических, иммунологических, экологических и психосоциальных факторов. В частности, на прогрессирование атопии влияет наличие мутаций гена филаггрина, время начала и тяжесть атопического дерматита, эпикутанная сенсибилизация к аэроаллергенам и колонизация бактериальными суперантигенами. Информация о наиболее значимых факторах, связанных с повышенным риском развития атопического марша, может быть полезна специалистам, оказывающим медицинскую помощь детям с аллергическими заболеваниями.

The development of atopic dermatitis at an early age and subsequent allergic rhinitis and asthma at a later age is known as the atopic march phenomenon. Despite the complexity and diversity of mechanisms of atopy development, it has been shown that atopic dermatitis and allergic respiratory diseases share a common pathogenesis. It was determined that the atopic dermatitis progression to bronchial asthma and rhinitis is associated with a complex interaction of genetic, immunologic, environmental, and psychosocial factors. In particular, the progression of atopy is influenced by the presence of filaggrin gene mutations, the onset and severity of atopic dermatitis, epicutaneous sensitization to aeroallergens, and colonization by bacterial superantigens. Despite significant progress in the studying of the role of skin barrier defects, impaired Th2 activation, hereditary component and environmental factors in the formation of atopy, to date no generally accepted algorithm for determining the risk of progression of atopic diseases has been developed. Information about the most significant factors associated with an increased risk of atopic march development may be useful for specialists providing medical care to children with allergic diseases.

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The authors declare that there are no conflicts of interest present.