medbioМедико-биологические проблемы жизнедеятельностиMedical and Biological Problems of Life Activity2074-2088Республиканский научно-практический центр радиационной медицины и экологии человека10.58708/2074-2088.2024-1(31)-136-148medbio-359Research ArticleОБМЕН ОПЫТОМEXPERIENCE EXCHANGEОбзор средств растительного происхождения в альтернативном гипотензивном и нейропротекторном лечении глаукомыReview of herbal remedies in alternative antihypertensive and neuroprotective treatment of glaucomaНагорноваЗ. М.NagornovaZ. M.

г. Иваново

СелезневА. В.SeleznevA. V.

г. Иваново

КорелинаВ. Е.KorelinaV. E.

г. С.-Петербург

КуроедовА. В.KuroyedovA. V.

г. Москва

ГазизоваИ. Р.GazizovaI. R.

г. С.-Петербург

https://orcid.org/0000-0003-4290-9952РожкоЮ. И.RazhkoYu. I.

г. Гомель

julia-rozhko@mail.ruБулахИ. А.BulakhI. A.

г. Иваново

ФГБОУ ВО «Ивановская государственная медицинская академия» Минздрава РоссииRussian FederationФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава РоссииRussian FederationФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России ; ФКУ «Центральный военный клинический госпиталь им. П.В. Мандрыка» Министерства обороны РФRussian FederationФГБУН «Институт мозга человека им. Н.П. Бехтеревой» РАНRussian FederationГУ «РНПЦ радиационной медицины и экологии человека»BelarusООО Медицинский центр «Ивастрамед»Russian Federation20240509202401136148Copyright © Нагорнова З.М., Селезнев А.В., Корелина В.Е., Куроедов А.В., Газизова И.Р., Рожко Ю.И., Булах И.А., 20242024Нагорнова З.М., Селезнев А.В., Корелина В.Е., Куроедов А.В., Газизова И.Р., Рожко Ю.И., Булах И.А.Nagornova Z.M., Seleznev A.V., Korelina V.E., Kuroyedov A.V., Gazizova I.R., Razhko Y.I., Bulakh I.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://medbio.ejournal.by/jour/article/view/359

В связи с тем, что глаукома – это хроническое, медленно прогрессирующее заболевание, пациенты зачастую разочаровываются в традиционных методах лечения, а это приводит к самостоятельному поиску иных лечебных стратегий. Целью данного обзора является обобщение данных о влиянии агентов растительного происхождения на течение глаукомного процесса и обсуждение обоснованности их применения. Проведен анализ работ, посвященных изучению нейропротекторного и гипотензивного действия средств альтернативной медицины. Результаты, представленные в обзоре, позволяют сделать вывод, что традиционная лечебная тактика сохраняет свою актуальность, а назначение любых альтернативных агентов требует особой осторожности и не отменяет необходимость адекватного контроля уровня внутриглазного давления.

Review of herbal remedies in alternative antihypertensive and neuroprotective treatment of glaucoma Due to the fact that glaucoma is a chronic, slowly progressive disease, patients are often disappointed in traditional treatment methods, and this leads to an independent search for other treatment strategies. The purpose of this review is to summarize data on the effect of herbal agents on the course of the glaucomatous process and discuss the validity of their use. An analysis of works devoted to the study of the neuroprotective and hypotensive effects of alternative medicine was carried out. The results presented in the review allow us to conclude that traditional treatment tactics remain relevant, and the prescription of any alternative agents requires special caution and does not eliminate the need for adequate control of intraocular pressure levels.

глаукомарастительные средстваальтернативное лечениевнутриглазное давлениенейропротекциячерникагингко билобаженьшеньмарихуанаglaucomaherbal remediesalternative treatmentintraocular pressureneuroprotectionblueberrygingko bilobaginsengmarijuanaReferencesGender differences in glaucoma / S. Zubasheva [et al.] // Russian Ophthalmological Journal. – 2021. – Vol. 14(3). – P. 120-123. (in Russ). doi: 10.21516/2072-0076-2021-14-3-120-123.Gender differences in glaucoma / S. Zubasheva [et al.] // Russian Ophthalmological Journal. – 2021. – Vol. 14(3). – P. 120-123. (in Russ). doi: 10.21516/2072-0076-2021-14-3-120-123.Quality of life and severity of glaucoma: A study using Glaucol-36 questionnaire at University Kebangsaan Malaysia medical centre (UKMMC) / H. Chandramohan [et al.] // Int. Med. J. – 2017. – Vol. 1(24). – P. 61-64.Quality of life and severity of glaucoma: A study using Glaucol-36 questionnaire at University Kebangsaan Malaysia medical centre (UKMMC) / H. Chandramohan [et al.] // Int. Med. J. – 2017. – Vol. 1(24). – P. 61-64.Ige, M. Herbal medicines in glaucoma treatment / M. Ige, J. Liu // Yale J Biol Med. – 2020. – Vol. 93(2). – P. 347-353.Ige, M. Herbal medicines in glaucoma treatment / M. Ige, J. Liu // Yale J Biol Med. – 2020. – Vol. 93(2). – P. 347-353.Rozhko, A.A. Capabilities of neuroimaging in determining the role of metabolic pathway of neurodegeneration in the pathophysiology of glaucoma / А.А. Rozhko // Ophthalmology Eastern Europe. – 2023. – Vol. 13(4). – Р. 386-399. (in Russ). doi: 10.34883/PI.2023.13.4.035.Rozhko, A.A. Capabilities of neuroimaging in determining the role of metabolic pathway of neurodegeneration in the pathophysiology of glaucoma / А.А. Rozhko // Ophthalmology Eastern Europe. – 2023. – Vol. 13(4). – Р. 386-399. (in Russ). doi: 10.34883/PI.2023.13.4.035.The proportion of complementary and alternative medicine utilization among Saudi population for eye care. Cross-sectional study / S. AlSalman [et al.] // Cureus. – 2013. – Vol. 13(2). – P. e13109. doi: 10.7759/cureus.13109.The proportion of complementary and alternative medicine utilization among Saudi population for eye care. Cross-sectional study / S. AlSalman [et al.] // Cureus. – 2013. – Vol. 13(2). – P. e13109. doi: 10.7759/cureus.13109.Use of complementary and alternative therapies by patients with eye diseases: A hospital-based cross-sectional study from Palestine / D. Jaber [et al.] // BMC Complementary Med. Ther. – 2021. – Vol. 21. – P. 3. doi: 10.1186/s12906-020-03188-9.Use of complementary and alternative therapies by patients with eye diseases: A hospital-based cross-sectional study from Palestine / D. Jaber [et al.] // BMC Complementary Med. Ther. – 2021. – Vol. 21. – P. 3. doi: 10.1186/s12906-020-03188-9.Binns, C.W. Problems and prospects: public health regulation of dietary supplements / C.W. Binns, M.K. Lee, A.H. Lee // Annu Rev Public Health. – 2018. – Vol. 39(1). – P. 403-420. doi: 10.1146/annurev-publhealth-040617-013638.Binns, C.W. Problems and prospects: public health regulation of dietary supplements / C.W. Binns, M.K. Lee, A.H. Lee // Annu Rev Public Health. – 2018. – Vol. 39(1). – P. 403-420. doi: 10.1146/annurev-publhealth-040617-013638.Two-year randomized, placebo-controlled study of black currant anthocyanins on visual field in glaucoma / H. Ohguro [et al.] // Ophthalmologica. – 2012. – Vol. 228(1). – P. 26-35. doi: 10.1159/000335961.Two-year randomized, placebo-controlled study of black currant anthocyanins on visual field in glaucoma / H. Ohguro [et al.] // Ophthalmologica. – 2012. – Vol. 228(1). – P. 26-35. doi: 10.1159/000335961.West, A.L. Evidence for the use of nutritional supplements and herbal medicines in common eye diseases / A.L. West, G.A. Oren, S.E. Moroi // Am J Ophthalmol. – 2006. – Vol. 141(1). – P. 157-166. doi: 10.1016/j.ajo.2005.07.033.West, A.L. Evidence for the use of nutritional supplements and herbal medicines in common eye diseases / A.L. West, G.A. Oren, S.E. Moroi // Am J Ophthalmol. – 2006. – Vol. 141(1). – P. 157-166. doi: 10.1016/j.ajo.2005.07.033.Yoshida, K. Black currant anthocyanins normalized abnormal levels of serum concentrations of endothelin-1 in patients with glaucoma / K. Yoshida, I. Ohguro, H. Ohguro // J Ocul Pharmacol Ther. – 2013. – Vol. 29(5). – P. 480-487. doi:10.1089/jop.2012.0198.Yoshida, K. Black currant anthocyanins normalized abnormal levels of serum concentrations of endothelin-1 in patients with glaucoma / K. Yoshida, I. Ohguro, H. Ohguro // J Ocul Pharmacol Ther. – 2013. – Vol. 29(5). – P. 480-487. doi:10.1089/jop.2012.0198.Effects of French maritime pine bark/bilberry fruit extracts on intraocular pressure for primary openangle glaucoma / K. Manabe [et al.] // J Clin Biochem Nutr. – 2021. – Vol. 68(1). – P. 67-72. doi:10.3164/JCBN.20-50.Effects of French maritime pine bark/bilberry fruit extracts on intraocular pressure for primary openangle glaucoma / K. Manabe [et al.] // J Clin Biochem Nutr. – 2021. – Vol. 68(1). – P. 67-72. doi:10.3164/JCBN.20-50.Ohguro, H. Effects of black currant anthocyanins on intraocular pressure in healthy volunteers and patients with glaucoma / H. Ohguro, I. Ohguro, S. Yagi // J Ocul Pharmacol Ther. – 2013. – Vol. 29(1). – P. 61-67. doi:10.1089/jop.2012.0071.Ohguro, H. Effects of black currant anthocyanins on intraocular pressure in healthy volunteers and patients with glaucoma / H. Ohguro, I. Ohguro, S. Yagi // J Ocul Pharmacol Ther. – 2013. – Vol. 29(1). – P. 61-67. doi:10.1089/jop.2012.0071.Ginkgo biloba extract and bilberry anthocyanins improve visual function in patients with normal tension glaucoma / S.H. Shim [et al.] // J Med Food. – 2012. – Vol. 15(9). – P. 818-823. doi: 10.1089/jmf.2012.2241.Ginkgo biloba extract and bilberry anthocyanins improve visual function in patients with normal tension glaucoma / S.H. Shim [et al.] // J Med Food. – 2012. – Vol. 15(9). – P. 818-823. doi: 10.1089/jmf.2012.2241.Two-year randomized, placebo-controlled study of black currant anthocyanins on visual field in glaucoma / H. Ohguro [et al.] // Ophthalmologica. – 2012. – Vol. 228(1). – P. 26-35. doi:10.1159/000335961.Two-year randomized, placebo-controlled study of black currant anthocyanins on visual field in glaucoma / H. Ohguro [et al.] // Ophthalmologica. – 2012. – Vol. 228(1). – P. 26-35. doi:10.1159/000335961.Acute cardioprotective and cardiotoxic effects of bilberry anthocyanins in ischemia-reperfusion injury: beyond concentration-dependent antioxidant activity / L. Ziberna [et al.] // Cardiovasc Toxicol. – 2010. – Vol. 10(4). – P. 283-294. doi:10.1007/s12012-010-9091-x.Acute cardioprotective and cardiotoxic effects of bilberry anthocyanins in ischemia-reperfusion injury: beyond concentration-dependent antioxidant activity / L. Ziberna [et al.] // Cardiovasc Toxicol. – 2010. – Vol. 10(4). – P. 283-294. doi:10.1007/s12012-010-9091-x.Procyanidin B2 and rutin in ginkgo biloba extracts protect human retinal pigment epithelial (RPE) cells from oxidative stress by modulating Nrf2 and Erk1/2 signalling / Y. Li [et al.] // Exp. Eye Res. – 2021. – Vol. 207(4). – P. 108586. doi: 10.1016/j.exer.2021.108586.Procyanidin B2 and rutin in ginkgo biloba extracts protect human retinal pigment epithelial (RPE) cells from oxidative stress by modulating Nrf2 and Erk1/2 signalling / Y. Li [et al.] // Exp. Eye Res. – 2021. – Vol. 207(4). – P. 108586. doi: 10.1016/j.exer.2021.108586.A network pharmacology-based strategy for predicting the protective mechanism of ginkgo biloba on damaged retinal ganglion cells / H. Yu. [et al.] // Chin. J Nat. Med. – 2022. – Vol. 20(1). – P. 54-66. doi: 10.1016/S1875-5364(21)60109-7.A network pharmacology-based strategy for predicting the protective mechanism of ginkgo biloba on damaged retinal ganglion cells / H. Yu. [et al.] // Chin. J Nat. Med. – 2022. – Vol. 20(1). – P. 54-66. doi: 10.1016/S1875-5364(21)60109-7.Diterpene ginkgolides meglumine injection inhibits apoptosis induced by optic nerve crush injury via modulating MAPKs signaling pathways in retinal ganglion cells / X.X. Fan [et al.] // J. Ethnopharmacol. – 2021. – Vol. 279. – P. 114371. doi: 10.1016/j.jep.2021.114371.Diterpene ginkgolides meglumine injection inhibits apoptosis induced by optic nerve crush injury via modulating MAPKs signaling pathways in retinal ganglion cells / X.X. Fan [et al.] // J. Ethnopharmacol. – 2021. – Vol. 279. – P. 114371. doi: 10.1016/j.jep.2021.114371.Noninvasive detection of mitochondrial dysfunction in ocular hypertension and primary openangle glaucoma / L.S. Geyman [et al.] // J Glaucoma. – 2018. – Vol. 27(7). – P. 592-599. doi: 10.1097/IJG.0000000000000980.Noninvasive detection of mitochondrial dysfunction in ocular hypertension and primary openangle glaucoma / L.S. Geyman [et al.] // J Glaucoma. – 2018. – Vol. 27(7). – P. 592-599. doi: 10.1097/IJG.0000000000000980.Effects of Ginkgo biloba on diseases related to oxidative stress / G. Achete de Souza [et al.] // Planta Med. – 2020. – Vol. 86(6). – P. 376-386. doi: 10.1055/a-1109-3405.Effects of Ginkgo biloba on diseases related to oxidative stress / G. Achete de Souza [et al.] // Planta Med. – 2020. – Vol. 86(6). – P. 376-386. doi: 10.1055/a-1109-3405.Neuroprotective effect of Ginkgo biloba extract against hypoxic retinal ganglion cell degeneration in vitro and in vivo / H.K. Cho [et al.] // J. Med. Food. – 2019. – Vol. 22(8). – P. 771-778. doi: 10.1089/jmf.2018.4350.Neuroprotective effect of Ginkgo biloba extract against hypoxic retinal ganglion cell degeneration in vitro and in vivo / H.K. Cho [et al.] // J. Med. Food. – 2019. – Vol. 22(8). – P. 771-778. doi: 10.1089/jmf.2018.4350.Ginkgo biloba extract and bilberry anthocyanins improve visual function in patients with normal tension glaucoma / S.H. Shim [et al.] // J. Med. Food. – 2012; – Vol. 15(9). – P. 818-823. doi: 10.1089/jmf.2012.2241.Ginkgo biloba extract and bilberry anthocyanins improve visual function in patients with normal tension glaucoma / S.H. Shim [et al.] // J. Med. Food. – 2012; – Vol. 15(9). – P. 818-823. doi: 10.1089/jmf.2012.2241.Ginkgo biloba affects microvascular morphology: a prospective optical coherence tomography angiography pilot study / M.C. Sabaner [et al.] // Int. Ophthalmol. – 2021. – Vol. 41(3). – P. 1053-1061. doi: 10.1007/s10792-020-01663-3.Ginkgo biloba affects microvascular morphology: a prospective optical coherence tomography angiography pilot study / M.C. Sabaner [et al.] // Int. Ophthalmol. – 2021. – Vol. 41(3). – P. 1053-1061. doi: 10.1007/s10792-020-01663-3.Effect of Ginkgo biloba on visual field and contrast sensitivity in Chinese patients with normal tension glaucoma: a randomized, crossover clinical trial / X. Guo [et al.] // Invest Ophthalmol Vis Sci. – 2014. – Vol. 55(1). – P. 110-116. doi: 10.1167/iovs.13-13168Effect of Ginkgo biloba on visual field and contrast sensitivity in Chinese patients with normal tension glaucoma: a randomized, crossover clinical trial / X. Guo [et al.] // Invest Ophthalmol Vis Sci. – 2014. – Vol. 55(1). – P. 110-116. doi: 10.1167/iovs.13-13168Kang, J.M. Ginkgo biloba and its potential role in glaucoma / J.M. Kang, S. Lin // Curr Opin Ophthalmol. – 2018. – Vol. 29(2). – P. 116-120. doi: 10.1097/ICU.0000000000000459.Kang, J.M. Ginkgo biloba and its potential role in glaucoma / J.M. Kang, S. Lin // Curr Opin Ophthalmol. – 2018. – Vol. 29(2). – P. 116-120. doi: 10.1097/ICU.0000000000000459.Lee, J. Effect of Ginkgo biloba extract on visual field progression in normal tension glaucoma / J. Lee, S.W. Sohn, C. Kee // J Glaucoma. – 2013. – Vol. 22(9). – P. 780-784. doi: 10.1097/IJG.0b013e3182595075.Lee, J. Effect of Ginkgo biloba extract on visual field progression in normal tension glaucoma / J. Lee, S.W. Sohn, C. Kee // J Glaucoma. – 2013. – Vol. 22(9). – P. 780-784. doi: 10.1097/IJG.0b013e3182595075.Mei, N. Review of Ginkgo biloba-induced toxicity, from experimental studies to human case reports / N. Mei, S. Lin // J Env Sci Heal. – 2017. – Vol. 35(1). – P. 1-28. doi: 10.5558/tfc68612-5.Mei, N. Review of Ginkgo biloba-induced toxicity, from experimental studies to human case reports / N. Mei, S. Lin // J Env Sci Heal. – 2017. – Vol. 35(1). – P. 1-28. doi: 10.5558/tfc68612-5.Sari, M.D. Ginkgo biloba extract effect on oxidative stress marker malonildialdehyde, redox enzyme gluthation peroxidase, visual field damage, and retinal nerve fiber layer thickness in primary open angle glaucoma / M.D. Sari, A.D. Sihotang, A. Lelo // Int J Pharm Tech Res. – 2016. – Vol. 9. – P. 158-166.Sari, M.D. Ginkgo biloba extract effect on oxidative stress marker malonildialdehyde, redox enzyme gluthation peroxidase, visual field damage, and retinal nerve fiber layer thickness in primary open angle glaucoma / M.D. Sari, A.D. Sihotang, A. Lelo // Int J Pharm Tech Res. – 2016. – Vol. 9. – P. 158-166.Baicalein, baicalin, and wogonin: protective effects against ischemia-induced neurodegeneration in the brain and retina / L. Pan [et al.] // Oxidative Med. Cell. Longev. – 2021. – Vol. 2021. – P. 8377362. doi: 10.1155/2021/8377362.Baicalein, baicalin, and wogonin: protective effects against ischemia-induced neurodegeneration in the brain and retina / L. Pan [et al.] // Oxidative Med. Cell. Longev. – 2021. – Vol. 2021. – P. 8377362. doi: 10.1155/2021/8377362.Baicalin suppresses glaucoma pathogenesis by regulating the PI3K/AKT signaling in vitro and in vivo / N. Zhao [et al.] // Bioengineered. – 2021. – Vol. 12. – P. 10187-10198. doi: 10.1080/21655979.2021.2001217Baicalin suppresses glaucoma pathogenesis by regulating the PI3K/AKT signaling in vitro and in vivo / N. Zhao [et al.] // Bioengineered. – 2021. – Vol. 12. – P. 10187-10198. doi: 10.1080/21655979.2021.2001217Shim, M.S. Role of cyclic AMP in the eye with glaucoma / M.S. Shim, K.Y. Kim, W.K. Ju // BMB Rep. – 2017. – Vol. 50. – P. 60-70. doi: 10.5483/BM-BRep.2017.50.2.200.Shim, M.S. Role of cyclic AMP in the eye with glaucoma / M.S. Shim, K.Y. Kim, W.K. Ju // BMB Rep. – 2017. – Vol. 50. – P. 60-70. doi: 10.5483/BM-BRep.2017.50.2.200.Terbutaline, forskolin and cAMP reduce secretion of aqueous humour in the isolated bovine eye / M. Shahidullah [et al.] // PLoS ONE. – 2020. – Vol. 15. – P. e0244253. doi: 10.1371/journal.pone.0244253.Terbutaline, forskolin and cAMP reduce secretion of aqueous humour in the isolated bovine eye / M. Shahidullah [et al.] // PLoS ONE. – 2020. – Vol. 15. – P. e0244253. doi: 10.1371/journal.pone.0244253.Protective efficacy of a dietary supplement based on forskolin, homotaurine, spearmint extract, and group B vitamins in a mouse model of optic nerve injury / F. Locri [et al.] // Nutrients. – 2019. – Vol. 11. – P. 2931. doi: 10.3390/nu11122931.Protective efficacy of a dietary supplement based on forskolin, homotaurine, spearmint extract, and group B vitamins in a mouse model of optic nerve injury / F. Locri [et al.] // Nutrients. – 2019. – Vol. 11. – P. 2931. doi: 10.3390/nu11122931.A dietary combination of forskolin with homotaurine, spearmint and B vitamins protects injured retinal ganglion cells in a rodent model of hypertensive glaucoma / M. Cammalleri [et al.] // Nutrients. – 2020. – Vol. 12. – P. 1189. doi: 10.3390/nu12041189.A dietary combination of forskolin with homotaurine, spearmint and B vitamins protects injured retinal ganglion cells in a rodent model of hypertensive glaucoma / M. Cammalleri [et al.] // Nutrients. – 2020. – Vol. 12. – P. 1189. doi: 10.3390/nu12041189.A double-blind, randomized clinical trial to evaluate the efficacy and safety of forskolin eye drops 1% in the treatment of open angle glaucoma – A comparative study / M. Majeed [et al.] // J. Clin. Trials. – 2014. – Vol. 4. – P. 1000184. doi: 10.4172/2167-0870.1000184.A double-blind, randomized clinical trial to evaluate the efficacy and safety of forskolin eye drops 1% in the treatment of open angle glaucoma – A comparative study / M. Majeed [et al.] // J. Clin. Trials. – 2014. – Vol. 4. – P. 1000184. doi: 10.4172/2167-0870.1000184.Oral scutellarin treatment ameliorates retinal thinning and visual deficits in experimental glaucoma / J. Zhu [et al.] // Front. Med. – 2021. – Vol. 8(3). – P. 681169. doi: 10.3389/fmed.2021.681169.Oral scutellarin treatment ameliorates retinal thinning and visual deficits in experimental glaucoma / J. Zhu [et al.] // Front. Med. – 2021. – Vol. 8(3). – P. 681169. doi: 10.3389/fmed.2021.681169.Effect on multifocal electroretinogram in persistently elevated intraocular pressure by erigeron breviscapus extract / X.J. Lu [et al.] // J. Ophthalmol. – 2011. – Vol. 4(4). – P. 349-352. doi: 10.3980/j.issn.2222-3959.2011.04.04.Effect on multifocal electroretinogram in persistently elevated intraocular pressure by erigeron breviscapus extract / X.J. Lu [et al.] // J. Ophthalmol. – 2011. – Vol. 4(4). – P. 349-352. doi: 10.3980/j.issn.2222-3959.2011.04.04.Metabolism and pharmacological mechanisms of active ingredients in Erigeron breviscapus / H. Fan [et al.] // Curr. Drug Metab. – 2021. – Vol. 22(1). – P. 24-39. doi: 10.2174/1389200221666201217093255.Metabolism and pharmacological mechanisms of active ingredients in Erigeron breviscapus / H. Fan [et al.] // Curr. Drug Metab. – 2021. – Vol. 22(1). – P. 24-39. doi: 10.2174/1389200221666201217093255.Lycium barbarum polysaccharides: extraction, purification, structural characterisation and evidence about hypoglycaemic and hypolipidaemic effects. A review. / A. Masci [et al.] // Food Chem. – 2018. – Vol. 254. – P. 377-389. doi: 10.1016/j.food-chem.2018.01.176.Lycium barbarum polysaccharides: extraction, purification, structural characterisation and evidence about hypoglycaemic and hypolipidaemic effects. A review. / A. Masci [et al.] // Food Chem. – 2018. – Vol. 254. – P. 377-389. doi: 10.1016/j.food-chem.2018.01.176.Lycium barbarum polysaccharides rescue neurodegeneration in an acute ocular hypertension rat model under preand posttreatment conditions / Y. Lakshmanan [et al.] // Investig. Ophthalmol. Vis. Sci. – 2019. – Vol. 60. – P. 2023-2033. doi: 10.1167/iovs.19-26752.Lycium barbarum polysaccharides rescue neurodegeneration in an acute ocular hypertension rat model under preand posttreatment conditions / Y. Lakshmanan [et al.] // Investig. Ophthalmol. Vis. Sci. – 2019. – Vol. 60. – P. 2023-2033. doi: 10.1167/iovs.19-26752.Posttreatment intervention with Lycium barbaru polysaccharides is neuroprotective in a rat model of chronic ocular hypertension / Y. Lakshmanan [et al.] // Investig. Ophthalmol. – 2019. – Vol. 60(14). – P. 4606-4618. doi: 10.1167/iovs.19-27886.Posttreatment intervention with Lycium barbaru polysaccharides is neuroprotective in a rat model of chronic ocular hypertension / Y. Lakshmanan [et al.] // Investig. Ophthalmol. – 2019. – Vol. 60(14). – P. 4606-4618. doi: 10.1167/iovs.19-27886.Lycium barbarum polysaccharides related RAGE and Abeta levels in the retina of mice with acute ocular hypertension and promote maintenance of blood retinal barrier / X.S. Mi [et al.] // Neural Regen. Res. – 2020. – Vol. 15(12). – P. 2344-2352. doi: 10.4103/1673-5374.284998.Lycium barbarum polysaccharides related RAGE and Abeta levels in the retina of mice with acute ocular hypertension and promote maintenance of blood retinal barrier / X.S. Mi [et al.] // Neural Regen. Res. – 2020. – Vol. 15(12). – P. 2344-2352. doi: 10.4103/1673-5374.284998.Lycium barbarum polysaccharides protects retinal ganglion cells against oxidative stress injury / L. Liu [et al.] // Neural Regen. Res. – 2020. – Vol. 15(8). – P. 1526-1531. doi: 10.4103/1673-5374.274349.Lycium barbarum polysaccharides protects retinal ganglion cells against oxidative stress injury / L. Liu [et al.] // Neural Regen. Res. – 2020. – Vol. 15(8). – P. 1526-1531. doi: 10.4103/1673-5374.274349.The intraocular pressure-lowering effect of persimmon leaves (Diospyros kaki) in a mouse model of glaucoma / H.R. Ahn [et al.] // Int. J. Mol. Sci. – 2019. – Vol. 20(21). – P. 5268. doi: 10.3390/ijms20215268.The intraocular pressure-lowering effect of persimmon leaves (Diospyros kaki) in a mouse model of glaucoma / H.R. Ahn [et al.] // Int. J. Mol. Sci. – 2019. – Vol. 20(21). – P. 5268. doi: 10.3390/ijms20215268.Persimmon (Diospyros Kaki L.): chemical properties, bioactive compounds and potential use in the development of new products – a review / J.R.V. Matheus [et al.] // Food Reviews International. – 2020. – Vol. 10. – P. 1-18. doi:10.1080/87559129.2020.1733597.Persimmon (Diospyros Kaki L.): chemical properties, bioactive compounds and potential use in the development of new products – a review / J.R.V. Matheus [et al.] // Food Reviews International. – 2020. – Vol. 10. – P. 1-18. doi:10.1080/87559129.2020.1733597.A mechanistic overview of triptolide and celastrol, natural products from Tripterygium wilfordii Hook F / S.R. Chen [et al.] // Front. Pharmacol. – 2018. – Vol. 9. – P. 104. doi: 10.3389/fphar.2018.00104.A mechanistic overview of triptolide and celastrol, natural products from Tripterygium wilfordii Hook F / S.R. Chen [et al.] // Front. Pharmacol. – 2018. – Vol. 9. – P. 104. doi: 10.3389/fphar.2018.00104.Li, J. Treatment of neurodegenerative diseases with bioactive components of Tripterygium wilfordii / J. Li, J. Hao // Am. J. Chin. – 2019. – Vol. 47(4). – P. 769-785. doi: 10.1142/S0192415X1950040X.Li, J. Treatment of neurodegenerative diseases with bioactive components of Tripterygium wilfordii / J. Li, J. Hao // Am. J. Chin. – 2019. – Vol. 47(4). – P. 769-785. doi: 10.1142/S0192415X1950040X.Saffron: chemical composition and neuroprotective activity / M.A. Maggi [et al.] // Molecules. – 2020. – Vol. 25(23). – P. 5618. doi: 10.3390/molecules25235618.Saffron: chemical composition and neuroprotective activity / M.A. Maggi [et al.] // Molecules. – 2020. – Vol. 25(23). – P. 5618. doi: 10.3390/molecules25235618.Plant growth promoting and antifungal asset of indigenous rhizobacteria secluded from saffron (Crocus sativus L.) rhizosphere / A. Rasool [et al.] // Microb Pathog. – 2021. – Vol. 150. – P. 104734. doi: 10.1016/j.micpath.2021.104734.Plant growth promoting and antifungal asset of indigenous rhizobacteria secluded from saffron (Crocus sativus L.) rhizosphere / A. Rasool [et al.] // Microb Pathog. – 2021. – Vol. 150. – P. 104734. doi: 10.1016/j.micpath.2021.104734.Potential health benefits of curcumin on female reproductive disorders: a review / D.A.M. Kamal [et al.] // Nutrients. – 2021. – Vol. 13(7). – P. 3126. doi: 10.3390/nu13093126.Potential health benefits of curcumin on female reproductive disorders: a review / D.A.M. Kamal [et al.] // Nutrients. – 2021. – Vol. 13(7). – P. 3126. doi: 10.3390/nu13093126.Curcumin minimises histopathological and immunological progression in the ankle joints of collagen-induced arthritis rats / T.T.M. Kevin [et al.] // Med. Health. – 2020. – Vol. 15. – P. 26-36. doi: 10.17576/MH.2020.1502.05.Curcumin minimises histopathological and immunological progression in the ankle joints of collagen-induced arthritis rats / T.T.M. Kevin [et al.] // Med. Health. – 2020. – Vol. 15. – P. 26-36. doi: 10.17576/MH.2020.1502.05.Wang, L. Treatment of glaucomatous optic nerve damage using ginsenoside Rg1 mediated by ultrasound targeted microbubble destruction / L. Wang, T. Cao, H. Chen [et al.] // Exp. Ther. Med. – 2018. – Vol. 15(1). – P. 300-304. doi: 10.3892/etm.2017.5386.Wang, L. Treatment of glaucomatous optic nerve damage using ginsenoside Rg1 mediated by ultrasound targeted microbubble destruction / L. Wang, T. Cao, H. Chen [et al.] // Exp. Ther. Med. – 2018. – Vol. 15(1). – P. 300-304. doi: 10.3892/etm.2017.5386.Effect of red ginseng on visual function and vision-related quality of life in patients with glaucoma. / K. Lee [et al.] // J. Ginseng Res. – 2021. – Vol. 45(6). – P. 676–682. doi: 10.1016/j.jgr.2021.03.004.Effect of red ginseng on visual function and vision-related quality of life in patients with glaucoma. / K. Lee [et al.] // J. Ginseng Res. – 2021. – Vol. 45(6). – P. 676–682. doi: 10.1016/j.jgr.2021.03.004.Neuroprotective effects of topical coenzyme Q10 + vitamin E in mechanic optic nerve injury model / S. Ekicier Acar [et al.] // Eur. J. Ophthalmol. – 2020. – Vol. 30(4). – P. 714-722. doi: 10.1177/1120672119833271.Neuroprotective effects of topical coenzyme Q10 + vitamin E in mechanic optic nerve injury model / S. Ekicier Acar [et al.] // Eur. J. Ophthalmol. – 2020. – Vol. 30(4). – P. 714-722. doi: 10.1177/1120672119833271.Skeletal protective effect of Coenzyme Q10: A review / S.O. Ekeuku [et al.] // Int. J. Pharmacol. – 2020. – Vol. 16. – P. 181-190. doi: 10.3923/ijp.2020.181.190.Skeletal protective effect of Coenzyme Q10: A review / S.O. Ekeuku [et al.] // Int. J. Pharmacol. – 2020. – Vol. 16. – P. 181-190. doi: 10.3923/ijp.2020.181.190.Effects of caffeinated coffee consumption on intraocular pressure, ocular perfusion pressure, and ocular pulse amplitude: a randomized controlled trial / A.Z. Jiwani [et al.] // Eye (Lond). – 2012. – Vol. 26(8). – P. 1122-1130. doi: 10.1038/eye.2012.113.Effects of caffeinated coffee consumption on intraocular pressure, ocular perfusion pressure, and ocular pulse amplitude: a randomized controlled trial / A.Z. Jiwani [et al.] // Eye (Lond). – 2012. – Vol. 26(8). – P. 1122-1130. doi: 10.1038/eye.2012.113.Chandrasekaran, S. Effects of caffeine on intraocular pressure: the Blue Mountains Eye Study / S. Chandrasekaran, E. Rochtchina, P. Mitchell // J Glaucoma. – 2005. – Vol. 14(6). – P. 504-507. doi: 10.1097/01.ijg.0000184832.08783.be.Chandrasekaran, S. Effects of caffeine on intraocular pressure: the Blue Mountains Eye Study / S. Chandrasekaran, E. Rochtchina, P. Mitchell // J Glaucoma. – 2005. – Vol. 14(6). – P. 504-507. doi: 10.1097/01.ijg.0000184832.08783.be.The relationship between caffeine and coffee consumption and exfoliation glaucoma or glaucoma suspect: a prospective study in two cohorts / L.R. Pasquale [et al.] // Invest Ophthalmol Vis Sci. – 2012. – Vol. 53(10). – P. 6427-6433. doi: 10.1167/iovs.12-10085.The relationship between caffeine and coffee consumption and exfoliation glaucoma or glaucoma suspect: a prospective study in two cohorts / L.R. Pasquale [et al.] // Invest Ophthalmol Vis Sci. – 2012. – Vol. 53(10). – P. 6427-6433. doi: 10.1167/iovs.12-10085.Frequency of a diagnosis of glaucoma in individuals who consume coffee, tea and/or soft drinks / C.M. Wu [et al.] // British Journal of Ophthalmology. – 2018. – Vol. 102(8). – P. 1127-1133. doi: 10.1136/bjophthalmol-2017-310924.Frequency of a diagnosis of glaucoma in individuals who consume coffee, tea and/or soft drinks / C.M. Wu [et al.] // British Journal of Ophthalmology. – 2018. – Vol. 102(8). – P. 1127-1133. doi: 10.1136/bjophthalmol-2017-310924.Milea, D. Flavonoids and glaucoma: revisiting therapies from the past / D. Milea, T. Aung // Graefes Arch Clin Exp Ophthalmol. – 2015. – Vol. 253(11). – P. 1839-1840. doi: 10.1007/s00417-015-3167-z.Milea, D. Flavonoids and glaucoma: revisiting therapies from the past / D. Milea, T. Aung // Graefes Arch Clin Exp Ophthalmol. – 2015. – Vol. 253(11). – P. 1839-1840. doi: 10.1007/s00417-015-3167-z.Neuroprotective role of epigallocatechin3-gallate in acute glaucoma via the nuclear factor-κB signalling pathway / W.H. Zhang [et al.] // Exp. Ther. Med. – 2021. – Vol. 22(5). – P. 1235. doi: 10.3892/etm.2021.10669.Neuroprotective role of epigallocatechin3-gallate in acute glaucoma via the nuclear factor-κB signalling pathway / W.H. Zhang [et al.] // Exp. Ther. Med. – 2021. – Vol. 22(5). – P. 1235. doi: 10.3892/etm.2021.10669.Green tea extract ameliorates ischemia-induced retinal ganglion cell degeneration in rats / Y. Yang [et al.] // Oxidative Med. Cell. Longev. – 2019. – Vol. 2019. – P. 8407206. doi: 10.1155/2019/8407206.Green tea extract ameliorates ischemia-induced retinal ganglion cell degeneration in rats / Y. Yang [et al.] // Oxidative Med. Cell. Longev. – 2019. – Vol. 2019. – P. 8407206. doi: 10.1155/2019/8407206.Effect of surfactant concentration and sterilization process on intraocular pressure-lowering activity of Delta(9)-tetrahydrocannabinol-valine-hemisuccinate (NB1111) nanoemulsions / C. Sweeney [et al.] // Drug Deliv. Transl. Res. – 2021. – Vol. 11. – P. 2096- 2107. doi: 10.1007/s13346-020-00871-9.Effect of surfactant concentration and sterilization process on intraocular pressure-lowering activity of Delta(9)-tetrahydrocannabinol-valine-hemisuccinate (NB1111) nanoemulsions / C. Sweeney [et al.] // Drug Deliv. Transl. Res. – 2021. – Vol. 11. – P. 2096- 2107. doi: 10.1007/s13346-020-00871-9.Cannabinoids in glaucoma patients: the neverending story / A. Passani [et al.] // J Clin Med. – 2020. – Vol. 9(12). – P. 1-20. doi: 10.3390/jcm9123978.Cannabinoids in glaucoma patients: the neverending story / A. Passani [et al.] // J Clin Med. – 2020. – Vol. 9(12). – P. 1-20. doi: 10.3390/jcm9123978.Hepler, R.S. Marihuana smoking and intraocular pressure / R.S. Hepler, I.R. Frank // JAMA. – 1971. – Vol. 217(10). – P. 1392. doi: 10.1001/jama.1971.03190100074024.Hepler, R.S. Marihuana smoking and intraocular pressure / R.S. Hepler, I.R. Frank // JAMA. – 1971. – Vol. 217(10). – P. 1392. doi: 10.1001/jama.1971.03190100074024.Effect of marihuana on intraocular and blood pressure in glaucoma / J.C. Merritt [et al.] // Ophthalmology. – 1980. – Vol. 87(3). – P. 222-228. doi: 10.1016/s0161-6420(80)35258-5.Effect of marihuana on intraocular and blood pressure in glaucoma / J.C. Merritt [et al.] // Ophthalmology. – 1980. – Vol. 87(3). – P. 222-228. doi: 10.1016/s0161-6420(80)35258-5.Abuhasira, R. Medical use of cannabis and cannabinoids containing products - Regulations in Europe and North America / R. Abuhasira, L. Shbiro, Y. Landschaft // European Journal of Internal Medicine. – 2018. – Vol. 49. – P. 2-6. doi: 10.1016/j.ejim.2018.01.001.Abuhasira, R. Medical use of cannabis and cannabinoids containing products - Regulations in Europe and North America / R. Abuhasira, L. Shbiro, Y. Landschaft // European Journal of Internal Medicine. – 2018. – Vol. 49. – P. 2-6. doi: 10.1016/j.ejim.2018.01.001.Katz, J. Facts vs fiction: the role of cannabinoids in the treatment of glaucoma / J. Katz, A.P. Costarides // Curr Ophthalmol Rep. – 2019. – Vol. 7(3). – P. 177-181. doi: 10.1007/s40135-019-00214-z.Katz, J. Facts vs fiction: the role of cannabinoids in the treatment of glaucoma / J. Katz, A.P. Costarides // Curr Ophthalmol Rep. – 2019. – Vol. 7(3). – P. 177-181. doi: 10.1007/s40135-019-00214-z.

The authors declare that there are no conflicts of interest present.