medbioМедико-биологические проблемы жизнедеятельностиMedical and Biological Problems of Life Activity2074-2088Республиканский научно-практический центр радиационной медицины и экологии человека10.58708/2074-2088.2023-1(29)-6-13medbio-290Research ArticleОБЗОРЫ И ПРОБЛЕМНЫЕ СТАТЬИREVIEWS AND PROBLEM ARTICLESПатофизиологические аспекты свободнорадикальных механизмов формирования кожных рубцовPathophysiological aspects of free radical mechanisms of formation of skin scarsЕвсеенкоД. А.EvseenkoD.ДундаровЗ. А.DundarovZ.ГалицкаяЮ. И.GalitskayaY.УО «Гомельский государственный медицинский университет»BelarusГУ «РНПЦ радиационной медицины и экологии человека»Belarus20232205202301613Copyright © Евсеенко Д.А., Дундаров З.А., Галицкая Ю.И., 20232023Евсеенко Д.А., Дундаров З.А., Галицкая Ю.И.Evseenko D., Dundarov Z., Galitskaya Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://medbio.ejournal.by/jour/article/view/290

В научной литературе отсутствуют полные научно обоснованные выводы о функциональном состоянии антиоксидантного статуса кожи, ее рубцах и возможностях их локальной коррекции в составе комплексной терапии. Проведен анализ источников литературных данных, отражающих вопросы комплексной терапии рубцовых изменений кожных покровов, с целью определения возможностей эффективного использования антиоксидантов в локальной коррекции нарушений окислительного стресса. Изучены патофизиологические аспекты свободнорадикальных механизмов формирования кожных рубцов. Клеточный пул, формирующий кожные покровы, в результате тканевого дыхания непрерывно продуцирует свободные радикалы. Как внешние, так и внутренние факторы среды могут приводить к нарушению динамического баланса в системе естественной антиоксидантной защиты организма, снижая потенциал ее биологической емкости. Агрессивному воздействию свободных радикалов могут подвергаться фосфобилипидный слой клеточной мембраны, ядерные и митохондриальные ДНК, тем самым вызывая или усугубляя имеющуюся патологию кожных покровов. Сниженная биологическая активность ферментативных и неферментативных звеньев системы антиоксидантной защиты организма не приводит к дезактивации свободных радикалов должным образом, что требует иных подходов к локальной терапии.

In the scientific literature, there are no complete scientifically substantiated conclusion about the functional state of the antioxidant status of the skin, its scars and the possibilities of their local correction as part of complex therapy. We have analyzed the literature data reflecting the issues of complex therapy of cicatricial changes in the skin in order to determine the feasibility for the effective use of antioxidants in the local correction of oxidative stress disorders. The pathophysiological aspects of free radical mechanisms of skin scar formation have been studied. The cell pool that forms the skin, as a result of tissue respiration, continuously produces free radicals. Both external and internal environmental factors can lead to disruption of the dynamic balance in the body's natural antioxidant defense system, reducing the potential of its biological capacity. The phospholipid layer of the cell membrane, nuclear and mitochondrial DNA can be exposed to aggressive action of free radicals, thereby causing or aggravating the existing pathology of the skin. Reduced biological activity of enzymatic and non-enzymatic components of the body's antioxidant defense system does not properly lead to the deactivation of free radicals, which requires other approaches to local therapy.

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The authors declare that there are no conflicts of interest present.