References

medbio

Медико-биологические проблемы жизнедеятельности

Medical and Biological Problems of Life Activity

2074-2088

Республиканский научно-практический центр радиационной медицины и экологии человека

medbio-272

Research Article

ОБЗОРЫ И ПРОБЛЕМНЫЕ СТАТЬИ

REVIEWS AND PROBLEM ARTICLES

Патофизиологические механизмы дискогенных поясничных радикулопатий (Обзор литературы)

Pathophysiological mechanisms of lumbar disc radiculopathies [literature review]

Цуканова

С. А.

Tsukanova

S. A.

noemail@neicon.ru

Жарикова

А. В.

Zharikova

A. V.

noemail@neicon.ru

Цуканов

А. Н.

Tsukanov

A. N.

noemail@neicon.ru

Кобылко

О. В.

Kobylko

O. V.

noemail@neicon.ru

Ходулев

В. И.

Hodulev

V. I.

noemail@neicon.ru

ГУ «РНПЦ радиационной медицины и экологии человека»Russian FederationГУ «Гомельская областная клиническая больница»Russian FederationГУ «РНПЦ неврологии и нейрохирургии»Russian Federation

2020

02032023

014858

2023

Цуканова С.А., Жарикова А.В., Цуканов А.Н., Кобылко О.В., Ходулев В.И.

Tsukanova S.A., Zharikova A.V., Tsukanov A.N., Kobylko O.V., Hodulev V.I.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://medbio.ejournal.by/jour/article/view/272

В статье представлен обзор современных данных о патофизиологических механизмах, лежащих в основе возникновения поясничных дискогенных радикулопатий. Описаны изменения микроциркуляции, нарушения аксонального транспорта при компрессии спинномозгового корешка (СМК) грыжей межпозвонкового диска (МПД), отражена динамика возможной регрессии грыж МПД. Описаны патофизиологические механизмы компрессии СМК при рострокаудальном подвывихе, возможность мультифокальной компрессии СМК. Отражена роль пульпозного ядра как грыжевого материала в инициации воспалительного процесса, роль иммунных механизмов при дискогенных поясничных радикулопатиях. Отражена центральная роль цитокинов в развитии воспаления и болевого синдрома при дискогенных поясничных радикулопатиях. Показана важность изучения патофизиологических процессов с целью совершенствования методов диагностики и лечения дискогенных поясничных радикулопатий.

The article provides an overview of current data on the pathophysiological mechanisms underlying the occurrence of lumbar disc radiculopathies. Microcirculation changes, axonal transport disorders at compression of the spinal root by a hernia of the intervertebral disc are described, the dynamics of a possible regression of intervertebral disc hernias is reflected. We have described the pathophysiological mechanisms of compression of the spinal root at rostrocaudal subluxation and the possibility of multifocal compression of the spinal root. We have reflected the role of the nucleus pulposus as a hernial material in the initiation of the inflammatory process, the role of immune mechanisms in lumbar disc radiculopathies. The crucial role of cytokines in the development of inflammation and pain syndrome in lumbar disc radiculopathies has been observed. The importance of studying pathophysiological processes in order to improve the methods of diagnosis and treatment of lumbar disc radiculopathies has been shown.

дискогенная поясничная радикулопатиягрыжа межпозвонкового дискапульпозное ядроцитокиныспинномозговой корешок

lumbar disc radiculopathyherniation of the intervertebral discnucleus pulposuscytokinesspinal root

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The authors declare that there are no conflicts of interest present.