medbioМедико-биологические проблемы жизнедеятельностиMedical and Biological Problems of Life Activity2074-2088Республиканский научно-практический центр радиационной медицины и экологии человекаmedbio-270Research ArticleОБЗОРЫ И ПРОБЛЕМНЫЕ СТАТЬИREVIEWS AND PROBLEM ARTICLESЦиркадные ритмы - как один из факторов регуляции биологии волосяных фолликулов (обзор литературы)Circadian rhythms - as one of the factors in the regulation of the biology of hair folliclesКраснобаеваМ. И.KrasnobaevaM. I.noemail@neicon.ruСоболевскаяИ. С.SobolevskayaI. S.noemail@neicon.ruМяделецО. Д.MyadeletsO. D.noemail@neicon.ruУО «Витебский государственный медицинский университет»Russian Federation202002032023013240Copyright © Краснобаева М.И., Соболевская И.С., Мяделец О.Д., 20232023Краснобаева М.И., Соболевская И.С., Мяделец О.Д.Krasnobaeva M.I., Sobolevskaya I.S., Myadelets O.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://medbio.ejournal.by/jour/article/view/270

В статье обзорного характера рассматриваются вопросы влияния циркадных ритмов на биологию волосяных фолликулов. Анализируются молекулярно-генетические аспекты биологических часов и вопросы их взаимосвязи с ростом и развитием волос. В основе хронобиологии волосяных фолликулов лежат несколько циркадных механизмов: «часы морфогенеза» (определяют индукцию и морфогенез в процессе эмбрионального развития волос); «циклический индуктор» (инициирует синхронизированную работу часов волоса); «десинхронизатор» (десинхронизирует работу часов волоса, например, при старении организма), «часы цикла волос» (управляет длительностью циклической активности волосяного фолликула) и автономная, связанная с клеточным циклом, секреторная активность соединительнотканных структур волосяного фолликула. Согласно ряду авторов, «циклический индуктор», «часы цикла волос» и «десинхронизатор» можно объединить в механизмы управления процессами апоптоза и митоза в волосяном фолликуле. Значительная часть статьи посвящена роли мелатонина в функционировании волосяного фолликула.

The article considers the influence of circadian rhythms on the biology of hair follicles. Molecular genetics aspects of the biological clock and the issues of their growth and hair development are analyzed.The chronobiology of hair follicles is based on several circadian images: «hours of morphogenesis» (determination of induction and morphogenesis in the process of embryonic hair development); «Cyclic inductor» (initiates the synchronized operation of the hair clock); «Desynchronized» (desynchronizes the work of hair, for example, during aging); According to a number of authors, the «cyclic inductor», «hair cycle clock» and «desynchronized» can be combined into mechanisms controlling the process of apoptosis and mitosis in the hair follicle.A significant part of the article is devoted to the role of melatonin in the functioning of the hair follicle.

волосяной фолликулциркадные ритмыцикл ростадесинхронозмелатонинhair folliclecircadian rhythmsgrowth cycledesynchronizesmelatoninReferencesA Meeting of Two Chronobiological Systems: Circadian Proteins Period1 and BMAL1 Modulate the Human Hair Cycle Clock / Y. Al-Nuaimi [et al.] // Journal of Investigative Dermatology. - 2014. - Vol. 134(3). - P. 610-619. doi:10.1038/jid.2013.366A Meeting of Two Chronobiological Systems: Circadian Proteins Period1 and BMAL1 Modulate the Human Hair Cycle Clock / Y. Al-Nuaimi [et al.] // Journal of Investigative Dermatology. - 2014. - Vol. 134(3). - P. 610-619. doi:10.1038/jid.2013.366Beckerandre, M. Identification of Nuclear Receptor mRNAs by RT-PCR Amplification of Conserved Zinc-Finger Motif Sequences / M. Beckerandre, E. Andre, J.F. Delamarter // Biochemical and Biophysical Research Communications. - 1993. - Vol. 194(3). - P. 1371-1379. doi:10.1006/bbrc.1993.1976Beckerandre, M. Identification of Nuclear Receptor mRNAs by RT-PCR Amplification of Conserved Zinc-Finger Motif Sequences / M. Beckerandre, E. Andre, J.F. Delamarter // Biochemical and Biophysical Research Communications. - 1993. - Vol. 194(3). - P. 1371-1379. doi:10.1006/bbrc.1993.1976External light activates hair follicle stem cells through eyes via an ipRGC-SCN-sympathetic neural pathway / S. M.-Y. Fan [et al.] // Proceedings of the National Academy of Sciences. - 2018. - Vol. 115(29). - P. E6880- E6889. doi:10.1073/pnas.1719548115External light activates hair follicle stem cells through eyes via an ipRGC-SCN-sympathetic neural pathway / S. M.-Y. Fan [et al.] // Proceedings of the National Academy of Sciences. - 2018. - Vol. 115(29). - P. E6880- E6889. doi:10.1073/pnas.1719548115Melatonin and the hair follicle / T.W. Fischer [et al.] // Journal of Pineal Research. - 2007. - Vol. 44. - P. 1-15. doi:10.1111/j.1600-079x.2007.00512.xMelatonin and the hair follicle / T.W. Fischer [et al.] // Journal of Pineal Research. - 2007. - Vol. 44. - P. 1-15. doi:10.1111/j.1600-079x.2007.00512.xGekakis N. Role of the CLOCK Protein in the Mammalian Circadian Mechanism / N. Gekakis // Science. - 1998. - Vol. 280(5369). - P. 1564-1569. doi:10.1126/science.280.5369.1564Gekakis N. Role of the CLOCK Protein in the Mammalian Circadian Mechanism / N. Gekakis // Science. - 1998. - Vol. 280(5369). - P. 1564-1569. doi:10.1126/science.280.5369.1564Differential Control of Bmal1 Circadian Transcription by REV-ERB and ROR Nuclear Receptors / F. Guillaumond [et al.] // Journal of Biological Rhythms. - 2005. - Vol. 20(5). - P. 391-403. doi:10.1177/0748730405277232Differential Control of Bmal1 Circadian Transcription by REV-ERB and ROR Nuclear Receptors / F. Guillaumond [et al.] // Journal of Biological Rhythms. - 2005. - Vol. 20(5). - P. 391-403. doi:10.1177/0748730405277232Hibino, T. Role of TGF-β2 in the human hair cycle / T. Hibino, T. Nishiyama // Journal of Dermatological Science. - 2004. - Vol. 35(1). - P. 9-18. doi:10.1016/j.jdermsci.2003.12.003Hibino, T. Role of TGF-β2 in the human hair cycle / T. Hibino, T. Nishiyama // Journal of Dermatological Science. - 2004. - Vol. 35(1). - P. 9-18. doi:10.1016/j.jdermsci.2003.12.003alpha-estradiol induces aromatase activity in intact human anagen hair follicles ex vivo / R. Hoffmann [et al.] // Experimental Dermatology. - 2002. - Vol. 11(4). - P. 376- 380. doi:10.1034/j.1600-0625.2002.110413.xalpha-estradiol induces aromatase activity in intact human anagen hair follicles ex vivo / R. Hoffmann [et al.] // Experimental Dermatology. - 2002. - Vol. 11(4). - P. 376- 380. doi:10.1034/j.1600-0625.2002.110413.xThe circadian molecular clock creates epidermal stem cell heterogeneity / P. Janich [et al.] // Nature. - 2011. - Vol. 480(7376). - P. 209-214. doi:10.1038/nature10649The circadian molecular clock creates epidermal stem cell heterogeneity / P. Janich [et al.] // Nature. - 2011. - Vol. 480(7376). - P. 209-214. doi:10.1038/nature10649Melatonin and its metabolites accumulate in the human epidermis in vivo and inhibit proliferation and tyrosinase activity in epidermal melanocytes in vitro / T.-K. Kim [et al.] // Molecular and Cellular Endocrinology. - 2015. - Vol. 404. - P. 1-8. doi:10.1016/j.mce.2014.07.024Melatonin and its metabolites accumulate in the human epidermis in vivo and inhibit proliferation and tyrosinase activity in epidermal melanocytes in vitro / T.-K. Kim [et al.] // Molecular and Cellular Endocrinology. - 2015. - Vol. 404. - P. 1-8. doi:10.1016/j.mce.2014.07.024Knutson, K.L. Associations between Sleep Loss and Increased Risk of Obesity and Diabetes / K.L. Knutson, E. Van Cauter // Annals of the New York Academy of Sciences. - 2008. - 1129(1). - P. 287-304. doi:10.1196/annals.1417.033Knutson, K.L. Associations between Sleep Loss and Increased Risk of Obesity and Diabetes / K.L. Knutson, E. Van Cauter // Annals of the New York Academy of Sciences. - 2008. - 1129(1). - P. 287-304. doi:10.1196/annals.1417.033A role of melatonin in neuroectodermal-mesodermal interactions: the hair follicle synthesizes melatonin and expresses functional melatonin receptors / H. Kobayashi [et al.] // The FASEB Journal. - 2005. - Vol. 19(12). - P. 1710-1712. doi:10.1096/fj.04-2293fjeA role of melatonin in neuroectodermal-mesodermal interactions: the hair follicle synthesizes melatonin and expresses functional melatonin receptors / H. Kobayashi [et al.] // The FASEB Journal. - 2005. - Vol. 19(12). - P. 1710-1712. doi:10.1096/fj.04-2293fjeLamia, K.A. Physiological significance of a peripheral tissue circadian clock / K.A. Lamia, K.-F. Storch, C.J. Weitz // Proceedings of the National Academy of Sciences. - 2008. - Vol. 105(39). - P. 15172-15177. doi:10.1073/pnas.0806717105Lamia, K.A. Physiological significance of a peripheral tissue circadian clock / K.A. Lamia, K.-F. Storch, C.J. Weitz // Proceedings of the National Academy of Sciences. - 2008. - Vol. 105(39). - P. 15172-15177. doi:10.1073/pnas.0806717105Circadian Clock Genes Contribute to the Regulation of Hair Follicle Cycling / K.K. Lin [et al.] // PLoS Genetics. - 2009. - Vol. 5(7). - e1000573. doi:10.1371/journal.pgen.1000573Circadian Clock Genes Contribute to the Regulation of Hair Follicle Cycling / K.K. Lin [et al.] // PLoS Genetics. - 2009. - Vol. 5(7). - e1000573. doi:10.1371/journal.pgen.1000573Lowrey, P.L. MAMMALIAN CIRCADIAN BIOLOGY: Elucidating Genome-Wide Levels of Temporal Organization / P.L. Lowrey, J.S. Takahashi // Annual Review of Genomics and Human Genetics. - 2004. - Vol. 5(1). - P. 407-441. doi:10.1146/annurev.genom.5.061903.175925Lowrey, P.L. MAMMALIAN CIRCADIAN BIOLOGY: Elucidating Genome-Wide Levels of Temporal Organization / P.L. Lowrey, J.S. Takahashi // Annual Review of Genomics and Human Genetics. - 2004. - Vol. 5(1). - P. 407-441. doi:10.1146/annurev.genom.5.061903.175925Maurer, M. The status quo and quo vadis of mast cells / M. Maurer, M. Metz // Experimental Dermatology. - 2005. - Vol. 14(12). - P. 923-929. doi:10.1111/j.1600-0625.2005.00369.xMaurer, M. The status quo and quo vadis of mast cells / M. Maurer, M. Metz // Experimental Dermatology. - 2005. - Vol. 14(12). - P. 923-929. doi:10.1111/j.1600-0625.2005.00369.xMillar, S.E. Molecular Mechanisms Regulating Hair Follicle Development / S.E. Millar // Journal of Investigative Dermatology. - 2002. - Vol. 118(2). - P. 216-225. doi:10.1046/j.0022-202x.2001.01670.xMillar, S.E. Molecular Mechanisms Regulating Hair Follicle Development / S.E. Millar // Journal of Investigative Dermatology. - 2002. - Vol. 118(2). - P. 216-225. doi:10.1046/j.0022-202x.2001.01670.xA Comprehensive Guide for the Accurate Classification of Murine Hair Follicles in Distinct Hair Cycle Stages / S. Müller-Röver [et al.] // Journal of Investigative Dermatology. - 2001. - Vol. 117(1). - P. 3-15. doi:10.1046/j.0022-202x.2001.01377.xA Comprehensive Guide for the Accurate Classification of Murine Hair Follicles in Distinct Hair Cycle Stages / S. Müller-Röver [et al.] // Journal of Investigative Dermatology. - 2001. - Vol. 117(1). - P. 3-15. doi:10.1046/j.0022-202x.2001.01377.xNadolnik, L.I. Stress and thyroid gland / L.I. Nadolnik // Biomeditsinskaya Khimiya. - 2010. - Vol. 56(4). - P. 443-456. doi:10.18097/pbmc20105604443Nadolnik, L.I. Stress and thyroid gland / L.I. Nadolnik // Biomeditsinskaya Khimiya. - 2010. - Vol. 56(4). - P. 443-456. doi:10.18097/pbmc20105604443Fiber growth initiation in hair follicles of goats treated with melatonin / A.J. Nixon [et al.] // Journal of Experimental Zoology. - 1993. - Vol. 267(1). - P. 47-56. doi:10.1002/jez.1402670108Fiber growth initiation in hair follicles of goats treated with melatonin / A.J. Nixon [et al.] // Journal of Experimental Zoology. - 1993. - Vol. 267(1). - P. 47-56. doi:10.1002/jez.1402670108Oshimori, N. Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation / N. Oshimori, E. Fuchs // Cell Stem Cell. - 2012. - Vol. 10(1). - P. 63-75. doi:10.1016/j.stem.2011.11.005Oshimori, N. Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation / N. Oshimori, E. Fuchs // Cell Stem Cell. - 2012. - Vol. 10(1). - P. 63-75. doi:10.1016/j.stem.2011.11.005Paus, R. Chronobiology of the Hair Follicle: Hunting the “Hair Cycle Clock” / R. Paus, S. Müller-Röver, V.A. Botchkarev // Journal of Investigative Dermatology Symposium Proceedings. - 1999. - Vol. 4(3). - P. 338-345. doi:10.1038/sj.jidsp.5640241Paus, R. Chronobiology of the Hair Follicle: Hunting the “Hair Cycle Clock” / R. Paus, S. Müller-Röver, V.A. Botchkarev // Journal of Investigative Dermatology Symposium Proceedings. - 1999. - Vol. 4(3). - P. 338-345. doi:10.1038/sj.jidsp.5640241Local circadian clock gates cell cycle progression of transient amplifying cells during regenerative hair cycling / M.V. Plikus [et al.] // Proceedings of the National Academy of Sciences. - 2013. - Vol. 110(23). - P. E2106- E2115. doi:10.1073/pnas.1215935110Local circadian clock gates cell cycle progression of transient amplifying cells during regenerative hair cycling / M.V. Plikus [et al.] // Proceedings of the National Academy of Sciences. - 2013. - Vol. 110(23). - P. E2106- E2115. doi:10.1073/pnas.1215935110Melatonin: reducing the toxicity and increasing the efficacy of drugs / R.J. Reiter [et al.] // Journal of Pharmacy and Pharmacology. - 2002. - Vol. 54(10). - P. 1299-1321. doi:10.1211/002235702760345374Melatonin: reducing the toxicity and increasing the efficacy of drugs / R.J. Reiter [et al.] // Journal of Pharmacy and Pharmacology. - 2002. - Vol. 54(10). - P. 1299-1321. doi:10.1211/002235702760345374Reppert, S.M. Coordination of circadian timing in mammals / S.M. Reppert, D.R. Weaver // Nature. - 2002. - Vol. 418(6901). - P. 935-941. doi:10.1038/nature00965.Reppert, S.M. Coordination of circadian timing in mammals / S.M. Reppert, D.R. Weaver // Nature. - 2002. - Vol. 418(6901). - P. 935-941. doi:10.1038/nature00965.Nuclear exclusion of the androgen receptor by melatonin / A. Rimler [et al.] // The Journal of Steroid Biochemistry and Molecular Biology. - 2002. - Vol. 81(1). - P. 77-84. doi:10.1016/s0960-0760(02)00050-xNuclear exclusion of the androgen receptor by melatonin / A. Rimler [et al.] // The Journal of Steroid Biochemistry and Molecular Biology. - 2002. - Vol. 81(1). - P. 77-84. doi:10.1016/s0960-0760(02)00050-xSchneider, M.R. The Hair Follicle as a Dynamic Miniorgan / M.R. Schneider, R. Schmidt-Ullrich, R. Paus // Current Biology. - 2009. - Vol. 19(3). - P. R132-R142. doi:10.1016/j.cub.2008.12.005Schneider, M.R. The Hair Follicle as a Dynamic Miniorgan / M.R. Schneider, R. Schmidt-Ullrich, R. Paus // Current Biology. - 2009. - Vol. 19(3). - P. R132-R142. doi:10.1016/j.cub.2008.12.005Murine skin as a target for melatonin bioregulation / A. Slominski [et al.] // Experimental Dermatology. - 1994. - Vol. 3(1). - P. 45-50. doi:10.1111/j.1600-0625.1994.tb00265.xMurine skin as a target for melatonin bioregulation / A. Slominski [et al.] // Experimental Dermatology. - 1994. - Vol. 3(1). - P. 45-50. doi:10.1111/j.1600-0625.1994.tb00265.xSlominski, A. The cutaneous serotoninergic/melatoninergic system: securing a place under the sun / A. Slominski, J. Wortsman, D.J. Tobin // The FASEB Journal. -, 2005. - Vol. 19(2). - P. 176-194. doi:10.1096/fj.04-2079rev.Slominski, A. The cutaneous serotoninergic/melatoninergic system: securing a place under the sun / A. Slominski, J. Wortsman, D.J. Tobin // The FASEB Journal. -, 2005. - Vol. 19(2). - P. 176-194. doi:10.1096/fj.04-2079rev.One molecule, many derivatives: A never-ending interaction of melatonin with reactive oxygen and nitrogen species? / D.- X. Tan [et al.] // Journal of Pineal Research. - 2007. - Vol. 42(1). - P. 28-42. doi:10.1111/j.1600-079x.2006.00407.xOne molecule, many derivatives: A never-ending interaction of melatonin with reactive oxygen and nitrogen species? / D.- X. Tan [et al.] // Journal of Pineal Research. - 2007. - Vol. 42(1). - P. 28-42. doi:10.1111/j.1600-079x.2006.00407.x

The authors declare that there are no conflicts of interest present.