medbioМедико-биологические проблемы жизнедеятельностиMedical and Biological Problems of Life Activity2074-2088Республиканский научно-практический центр радиационной медицины и экологии человекаmedbio-264Research ArticleКЛИНИЧЕСКАЯ МЕДИЦИНАCLINICAL MEDICINEПролонгированное выделение вируса SARS- CoV- 2 при инфекции COVID-19 у пациентов с онкогематологическими заболеваниямиProlonged SARS-CoV-2 shedding at COVID-19 infection in patients with oncohematological diseasesШепетькоМ. М.Schepet'koM. M.noemail@neicon.ruСтомаИ. О.StomaI. O.noemail@neicon.ruГУ «Минский НПЦ хирургии, трансплантологии и гематологии»Russian FederationУО «Гомельский государственный медицинский университет»Russian Federation20210203202301151156Copyright © Шепетько М.М., Стома И.О., 20232023Шепетько М.М., Стома И.О.Schepet'ko M.M., Stoma I.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://medbio.ejournal.by/jour/article/view/264

Пациенты с онкологическими и онкогематологическими заболеваниями после трансплантации солидных органов или костного мозга часто переносят инфекцию COVID-19 в тяжелой форме, что нередко заканчивается летальным исходом. В исследовании приняло участие 36 пациентов с различными онкогематологическими заболеваниями и подтвержденной инфекцией COVID-19. Верификация инфекционного процесса выполнялась методом ПЦР в режиме реального времени с обнаружением РНК вируса из рото- и носоглотки в течение первых двух суток от момента появления симптомов инфекции COVID-19. Группу контроля составили 24 пациента с подтвержденной COVID-19 инфекцией методом ПЦР без онкогематологической патологии. Длительность выделения РНК вируса SARS-CoV-2 (положительный ПЦР-анализ назо/орофарингеального мазка) у пациентов с онкогематологическими заболеваниями и инфекций COVID-19 вне зависимости от клинических симптомов варьировала от 11 до 59 дней (медиана 31 день, интерквартильный интервал 25-38), а в группе контроля - от 9 до 26 дней (медиана 14 дней, интерквартильный интервал 11-18). У большинства пациентов с онкогематологическими заболеваниями имеет место пролонгированное выделение РНК вируса SARS-CoV-2 при COVID-19 инфекции, подтвержденное методом ПЦР (назо/орофарингеальный мазок) в режиме реального времени.

Patients with oncological and oncohematological diseases, after transplantation of solid organs or bone marrow, frequently suffer from severe COVID-19 infection, which is often fatal. The study involved 36 patients with various oncohematological diseases and confirmed COVID-19 infection. Verification of the infectious process was performed by real-time PCR with detection of the RNA of the virus from the oropharynx and nasopharynx within the first two days from the onset of symptoms of COVID-19 infection. The control group consisted of 24 patients with confirmed COVID-19 infection by PCR without oncohematological pathology. The duration of viral SARS-CoV-2 shedding (positive PCR analysis of naso / oropharyngeal swab) in patients with hematological diseases and COVID-19 infections, regardless of clinical symptoms, ranged from 11 to 59 days (median 31 days, interquartile range 25-38), and in the control group - from 9 to 26 days (median 14 days, interquartile range 11-18).In most patients with oncohematological diseases, there is a prolonged shedding of SARS-CoV-2 virus RNA during COVID-19 infection, confirmed by real-time PCR (naso/oropharyngeal swab).

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The authors declare that there are no conflicts of interest present.