medbioМедико-биологические проблемы жизнедеятельностиMedical and Biological Problems of Life Activity2074-2088Республиканский научно-практический центр радиационной медицины и экологии человекаmedbio-254Research ArticleМЕДИКО-БИОЛОГИЧЕСКИЕ ПРОБЛЕМЫMEDICAL-BIOLOGICAL PROBLEMSРоль генетического полиморфизма и межгенного взаимодействия в повышении вероятности развития патологической игровой зависимостиRole of genetic polymorphism and intergene interference in increased probability of the pathological game dependence developmentСнытковЕ. В.SnytkovE. V.noemail@neicon.ruКипеньВ. Н.KipenV. N.noemail@neicon.ruМельновС. Б.MelnovS. B.noemail@neicon.ruУО «МГЭИ им. А.Д. Сахарова» БГУRussian FederationГНУ «Институт генетики и цитологии НАН Беларуси»Russian Federation202102032023017280Copyright © Снытков Е.В., Кипень В.Н., Мельнов С.Б., 20232023Снытков Е.В., Кипень В.Н., Мельнов С.Б.Snytkov E.V., Kipen V.N., Melnov S.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://medbio.ejournal.by/jour/article/view/254

В статье приведены результаты молекулярно-генетического анализа 13 полиморфных вариантов генов ESR1, AS3MT, PECR, NT5C2, BUB1B-PAK6, EPHX2, HIP1, MUC7, CACNA1C, CHRNA4, DGKI и PIK3C2A пациентов, страдающих патологической игровой зависимостью. Проведен анализ частоты распространенности генотипов и аллелей, а также анализ межгенных взаимодействий для определения их сочетанного воздействия на риск развития патологической игровой зависимости. Установлено, что локусы rs17504622, rs73229090 (EPHX2) и rs237238 (HIP1) статистически значимо ассоциированы с повышенной вероятностью развития патологической игровой зависимости.

The article presents the results of molecular genetic analysis of 13 polymorphic variants of genes ESR1, AS3MT, PECR, NT5C2, BUB1B-PAK6, EPHX2, HIP1, MUC7, CACNA1C, CHRNA4, DGKI and PIK3C2A of patients suffering from pathological gambling addiction. The analysis of the frequency of prevalence of genotypes and alleles, as well as the analysis of intergenic interactions to determine their combined impact on the risk of developing pathological gambling addiction. The loci rs17504622, rs73229090 (EPHX2), and rs237238 (HIP1) were found

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The authors declare that there are no conflicts of interest present.