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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medbio</journal-id><journal-title-group><journal-title xml:lang="ru">Медико-биологические проблемы жизнедеятельности</journal-title><trans-title-group xml:lang="en"><trans-title>Medical and Biological Problems of Life Activity</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2074-2088</issn><publisher><publisher-name>Республиканский научно-практический центр радиационной медицины и экологии человека</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">medbio-171</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МЕДИКО-БИОЛОГИЧЕСКИЕ ПРОБЛЕМЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>MEDICAL-BIOLOGICAL PROBLEMS</subject></subj-group></article-categories><title-group><article-title>Ультраструктурные особенности стремечка у пациентов с отосклерозом</article-title><trans-title-group xml:lang="en"><trans-title>Ultrastructural features of the stapes in patients with otosclerosis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гребень</surname><given-names>Н. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Greben</surname><given-names>N. .</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Малец</surname><given-names>Е. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Malets</surname><given-names>A. .</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рябцева</surname><given-names>С. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Ryabceva</surname><given-names>S. .</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Порадовский</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Poradovsky</surname><given-names>A. .</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сташкевич</surname><given-names>Е. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Stashkevich</surname><given-names>H. .</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Семёник</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Siamionik</surname><given-names>I. .</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ГУ «РНПЦ оториноларингологии»</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-2"><institution>Институт физиологии Национальной академии наук Беларуси</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>02</day><month>03</month><year>2023</year></pub-date><volume>0</volume><issue>2</issue><fpage>60</fpage><lpage>65</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Гребень Н.И., Малец Е.Л., Рябцева С.Н., Порадовский А.А., Сташкевич Е.Ю., Семёник И.А., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Гребень Н.И., Малец Е.Л., Рябцева С.Н., Порадовский А.А., Сташкевич Е.Ю., Семёник И.А.</copyright-holder><copyright-holder xml:lang="en">Greben N..., Malets A..., Ryabceva S..., Poradovsky A..., Stashkevich H..., Siamionik I...</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://medbio.ejournal.by/jour/article/view/171">https://medbio.ejournal.by/jour/article/view/171</self-uri><abstract><p>Проведен анализ ультраструктурных изменений ножек и головки стремечка 18 пациентов, страдавших отосклерозом. Материал для исследования взят во время оперативного лечения заболевания (проведения стапедопластики). В процессе анализа структурных изменений стремечка были выявлены очаговые изменения костной ткани, характерные для активного процесса резорбции и лизиса с активацией остеоцитов, а также проявления активной минерализации ткани, отсутствие её перестройки в классический вариант пластинчатой кости, фокусы аномального остеогенеза. Данное исследование показало наличие патологических изменений в стремечке у пациентов с отосклерозом.</p></abstract><trans-abstract xml:lang="en"><p>The analysis of ultrastructural changes in stapes (pedicles and head) of 18 patients with otosclerosis was carried out. The material for the study was taken during the surgical treatment of the disease (stapedoplasty). The structural changes in stapes were found: focal changes in the bone tissue were characteristic of the active process of resorption and lysis with osteocytes activation, as well as manifestations of active mineralization of bone, the absence of its restructuring into the classic lamellar bone, and foci of abnormal osteogenesis. This study showed ultrastructural changes in stapes in patients with otosclerosis.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>стремечко</kwd><kwd>отосклероз</kwd><kwd>ультраструктурные изменения костной ткани</kwd></kwd-group><kwd-group xml:lang="en"><kwd>stapes</kwd><kwd>otosclerosis</kwd><kwd>ultrastructural changes in bone tissue</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Отосклероз. Клинические рекомендации / Н.А. Дайхес [и др.] // М-во здравоохранения Рос. 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