medbioМедико-биологические проблемы жизнедеятельностиMedical and Biological Problems of Life Activity2074-2088Республиканский научно-практический центр радиационной медицины и экологии человекаmedbio-160Research ArticleКЛИНИЧЕСКАЯ МЕДИЦИНАCLINICAL MEDICINEИНФЕКЦИОННЫЕ ОСЛОЖНЕНИЯ, СОПРОВОЖДАЮЩИЕ ТРАНСПЛАНАТАЦИЮ ПОЧКИ: ПРОБЛЕМЫ И ПЕРСПЕКТИВЫINFECTIOUS SEQUELAE ACCOMPANYING THE KIDNEY TRANSPLANTATION: PROBLEMS AND PROSPECTSСвистуноваЕ. А.SvistunovaE. .noemail@neicon.ruШевченкоН. И.ShevchenkoN. .noemail@neicon.ruРусаленкоМ. Г.RusalenkoM. .noemail@neicon.ruГУ "РНПЦ радиационной медицины и экологии человека"Russian Federation20160203202301195203Copyright © Свистунова Е.А., Шевченко Н.И., Русаленко М.Г., 20232023Свистунова Е.А., Шевченко Н.И., Русаленко М.Г.Svistunova E..., Shevchenko N..., Rusalenko M...Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://medbio.ejournal.by/jour/article/view/160

Результаты анализа зарегистрированных инфекционных осложнений после проведения аллогенной трансплантации почки на фоне иммуносупрессивной терапии и оценка антимикробной, противовирусной и противогрибковой терапии позволили выделить факторы риска и предложить организационные решения для улучшения эффективности проводимых диагностических и лечебных мероприятий.

The authors conducted the analysis of determined infectious sequelae of the early postsurgical period in the patients after the allogenic kidney transplantation. The microbiological monitoring allows revealing some tendencies by species of determined microorganisms, the sensitivity and resistance of some strains typical for the institution. The estimation of conducted antimicrobial and antifungal therapy combined with the immunosuppress therapy accompanying the kidney transplantation and approved with the regulatory documentation of the Ministry of Health of the Republic of Belarus allows determining the risk factors of infection development in the recipients and offering some organizational decisions to improve the efficiency of the high-technology dedicated medical assistance provided to the patients.

трансплантация почкиинфекционные осложнениямикрофлорарезистентность штаммовkidney transplantationinfectious sequelaemicrobial florastrains resistanceReferencesInfectious complications after kidney transplantation: current epidemiology and associated risk factors / G.J. Alangaden [et al.] // Clin Transplant. - 2006. - Vol. 20, - P. 401- 409.Infectious complications after kidney transplantation: current epidemiology and associated risk factors / G.J. Alangaden [et al.] // Clin Transplant. - 2006. - Vol. 20, - P. 401- 409.Развитие гнойно-септических осложнений на фоне иммуносупрессивной терапии у больных с аллотрансплантированной почкой / Е.П. Волынчик и др. // II Всероссийский съезд по трансплантологии. Москва, 17-19 октября. Вестник трансплантологии и искусственных органов. - 2003. - №3. - С. 67.Развитие гнойно-септических осложнений на фоне иммуносупрессивной терапии у больных с аллотрансплантированной почкой / Е.П. Волынчик и др. // II Всероссийский съезд по трансплантологии. Москва, 17-19 октября. Вестник трансплантологии и искусственных органов. - 2003. - №3. - С. 67.Готье, С.В. Инфекции в трансплантологии / С.В. Готье // Под редакцией С.В. Готье. М., 2010,Готье, С.В. Инфекции в трансплантологии / С.В. Готье // Под редакцией С.В. Готье. М., 2010,Predictive factors of infection in the first year after kidney transplantation / P. Galindo Sacristan [et al.] // Transplant Proc. - 2013. - Vol.45. - № 10, - P. 3620-3623.Predictive factors of infection in the first year after kidney transplantation / P. Galindo Sacristan [et al.] // Transplant Proc. - 2013. - Vol.45. - № 10, - P. 3620-3623.Urinary tract infections in a cohort of kidney transplant recipients / A. Bispo [et al.] // Acta Med. Port. - 2014. - Vol. 27. - № 3. - P. 64-71.Urinary tract infections in a cohort of kidney transplant recipients / A. Bispo [et al.] // Acta Med. Port. - 2014. - Vol. 27. - № 3. - P. 64-71.Gancyclovir prophylaxis to prevent CMV disease in kidney recipients undergoing antilymphocyte globulin treatment for acute rejection / M.J. Dickenmann [et al.] // ClinMicrobiol. Infect. - 2014. - Vol. 4. - P. 337-339.Gancyclovir prophylaxis to prevent CMV disease in kidney recipients undergoing antilymphocyte globulin treatment for acute rejection / M.J. Dickenmann [et al.] // ClinMicrobiol. Infect. - 2014. - Vol. 4. - P. 337-339.Post-trasplant diabetes mellitus and CMV seropositive status after renal transplantation: meta-analysis of clinical studies / F. Febrizi [et al.] // Am J Transplant. - 2005. - Vol.5. - P. 2433-2440,Post-trasplant diabetes mellitus and CMV seropositive status after renal transplantation: meta-analysis of clinical studies / F. Febrizi [et al.] // Am J Transplant. - 2005. - Vol.5. - P. 2433-2440,Cohn, J. Immunization for renal transplant candidates and recipients / J. Cohn, E.A. Blumberg // Nature Clin Practice Nephrology. 2009. - Vol.5. - P. 46-53.Cohn, J. Immunization for renal transplant candidates and recipients / J. Cohn, E.A. Blumberg // Nature Clin Practice Nephrology. 2009. - Vol.5. - P. 46-53.Demand for evaluation of vaccination antibody titers in children considered for renal transplantation / M. Prelog [et al.] // Pediatr Transplant. - 2007. - Vol. 11. - P. 73-76.Demand for evaluation of vaccination antibody titers in children considered for renal transplantation / M. Prelog [et al.] // Pediatr Transplant. - 2007. - Vol. 11. - P. 73-76.Zeier, M. Preparation of the dialysis patient for transplantation / M. Zeier, E. Ritz // Nephrol Dial Transplant. - 2002. - Vol. 17. - P. 552-556.Zeier, M. Preparation of the dialysis patient for transplantation / M. Zeier, E. Ritz // Nephrol Dial Transplant. - 2002. - Vol. 17. - P. 552-556.Antibiotic selective pressure and development of bacterial resistance detected in bacteriuria following kidney transplantation / G. Pouladfar [et al.] // TransplantProc- 2015. - Vol. 47(4). - P. 1131-1135.Antibiotic selective pressure and development of bacterial resistance detected in bacteriuria following kidney transplantation / G. Pouladfar [et al.] // TransplantProc- 2015. - Vol. 47(4). - P. 1131-1135.Bacterial and fungal infections in the early post-transplant period after kidney transplantation: etiological agents and their susceptibility / D. Kawecki [et al.] // Transplant Proc. - 2014. - Vol. 46(8). - P. 2733-2737.Bacterial and fungal infections in the early post-transplant period after kidney transplantation: etiological agents and their susceptibility / D. Kawecki [et al.] // Transplant Proc. - 2014. - Vol. 46(8). - P. 2733-2737.Evaluation of Infectious Complications in the First Year After Kidney Transplantation / А. Yalci [et al.] // TransplantProc. - 2015. - Vol. 47(5). - P. 1429-1432.Evaluation of Infectious Complications in the First Year After Kidney Transplantation / А. Yalci [et al.] // TransplantProc. - 2015. - Vol. 47(5). - P. 1429-1432.Klebsiella spp. urinary tract infections during first year after renal transplantation / J. Gołębiewska [et al.] // TransplantProc. - 2014. - Vol. 46(8). - P. 2748-2751.Klebsiella spp. urinary tract infections during first year after renal transplantation / J. Gołębiewska [et al.] // TransplantProc. - 2014. - Vol. 46(8). - P. 2748-2751.Study of the risk factors related to acquisition of urinary tract infections in patients submitted to renal transplant / M.G. Menegueti [et al.] // Rev Soc Bras Med Trop. - 2015. - Vol. 48(3). - P. 285-290,Study of the risk factors related to acquisition of urinary tract infections in patients submitted to renal transplant / M.G. Menegueti [et al.] // Rev Soc Bras Med Trop. - 2015. - Vol. 48(3). - P. 285-290,Urinary Tract Infections in Kidney Transplant Patients Due to Escherichia coli and Klebsiella pneumoniae - Producing Extended-Spectrum β-Lactamases: Risk Factors and Molecular Epidemiology / M.J. Espinar [et al.] // PLOS ONE. - 2015. - Vol.3. - P. 1-11.Urinary Tract Infections in Kidney Transplant Patients Due to Escherichia coli and Klebsiella pneumoniae - Producing Extended-Spectrum β-Lactamases: Risk Factors and Molecular Epidemiology / M.J. Espinar [et al.] // PLOS ONE. - 2015. - Vol.3. - P. 1-11.Levofloxacin for BK virus prophylaxis following kidney transplantation: a randomized clinical trial / G.A. Knoll [et al.] // JAMA. - 2014. - №26. - Vol. 312(20). - P. 2106-2114.Levofloxacin for BK virus prophylaxis following kidney transplantation: a randomized clinical trial / G.A. Knoll [et al.] // JAMA. - 2014. - №26. - Vol. 312(20). - P. 2106-2114.Impact of graft infection on long-term survival after kidney transplant / А. Zukowska [et al.] // TransplantProc. - 2014. - Vol. 46(8). - P. 2752-2754.Impact of graft infection on long-term survival after kidney transplant / А. Zukowska [et al.] // TransplantProc. - 2014. - Vol. 46(8). - P. 2752-2754.Invasive Fungal Infections After Kidney Transplantation: A Single-center Experience / T. Santos [et al.] / TransplantProc. - 2015. - Vol. 47(4). - P. 971-975.Invasive Fungal Infections After Kidney Transplantation: A Single-center Experience / T. Santos [et al.] / TransplantProc. - 2015. - Vol. 47(4). - P. 971-975.Candida arteritis in kidney transplant recipients: case report and review of the literature / A. Dębska-Ślizień [et al.] // TransplInfectDis. - 2015. - Vol. 17(3). - P. 449-455.Candida arteritis in kidney transplant recipients: case report and review of the literature / A. Dębska-Ślizień [et al.] // TransplInfectDis. - 2015. - Vol. 17(3). - P. 449-455.

The authors declare that there are no conflicts of interest present.