medbioМедико-биологические проблемы жизнедеятельностиMedical and Biological Problems of Life Activity2074-2088Республиканский научно-практический центр радиационной медицины и экологии человекаmedbio-104Research ArticleОБЗОРЫ И ПРОБЛЕМНЫЕ СТАТЬИREVIEWS AND PROBLEM ARTICLESИммунологические механизмы эффекторного звена системы иммунитета при аллотрансплантацииThe immunologic mechanism of the immune system effector am in the allotransplantationЗыблеваС. В.ZyblevaS. .noemail@neicon.ruЗыблевС. Л.ZyblevS. .noemail@neicon.ruГУ «РНПЦ радиационной медицины и экологии человека», г. Гомель, БеларусьRussian Federation202002032023021324Copyright © Зыблева С.В., Зыблев С.Л., 20232023Зыблева С.В., Зыблев С.Л.Zybleva S..., Zyblev S...Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://medbio.ejournal.by/jour/article/view/104

Авторы описывают молекулярные и клеточные процессы, сопровождающие эффекторное звено иммунного ответа при трансплантации органов. С учетом различных исследовательских работ приводятся значимые патогенетические аспекты клеточного и гуморального механизмов повреждения трансплантата, особенности формирования иммунологической толерантности и возможности применения результатов исследований в развитии подходов к иммуносупрессивной терапии.

The authors describe molecular and cellular processes accompanying the effector arm of the immune response in the organ transplantation. Significant pathogenic aspects of cellular and humoral mechanism of a graft damaging, the features of immunologic tolerance forming and possibility to apply the research results in the development of an immunosuppressive therapy approach are considered, taking into consideration different researches.

трансплантация органовклеточный и гуморальный трансплантационный иммунитетиммунологическая толерантностьorgan transplantationcellular and humoral transplantation immunityimmune toleranceReferencesInstruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells / D. Amsen [et al.] // Cell. - 2004. - Vol. 117. - P. 515-526.Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells / D. Amsen [et al.] // Cell. - 2004. - Vol. 117. - P. 515-526.Immune privilege induced by regulatory T cells in transplantation tolerance / S.P. Cobbold [et al.] // Immunol Rev. - 2006. - Vol. 213. - P. 239-255.Immune privilege induced by regulatory T cells in transplantation tolerance / S.P. Cobbold [et al.] // Immunol Rev. - 2006. - Vol. 213. - P. 239-255.Colvin, R.B. Antibody-mediated organ-allograft rejection / R.B. Colvin, R.N. Smith // Nat Rev Immunol. - 2005. - Vol. 5. - P. 807-817.Colvin, R.B. Antibody-mediated organ-allograft rejection / R.B. Colvin, R.N. Smith // Nat Rev Immunol. - 2005. - Vol. 5. - P. 807-817.Notch: control of lymphocyte differentiation in the periphery / M.J. Dallman [et al.] // Curr Opin Immunol. - 2005. - Vol. 17. - P. 259-266.Notch: control of lymphocyte differentiation in the periphery / M.J. Dallman [et al.] // Curr Opin Immunol. - 2005. - Vol. 17. - P. 259-266.Delikouras, A. Transplant accommodation / A. Delikouras, A. Dorling // Am J Transplant. - 2003. - Vol. 3. - P. 917-918.Delikouras, A. Transplant accommodation / A. Delikouras, A. Dorling // Am J Transplant. - 2003. - Vol. 3. - P. 917-918.Endothelial cell cyto-protection induced in vitro by allo- or xenoreactive antibodies is mediated by signaling through adenosine A2 receptors / A. Delikouras [et al.] // Eur J Immunol. - 2003. - Vol. 33. - P. 3127- 3135.Endothelial cell cyto-protection induced in vitro by allo- or xenoreactive antibodies is mediated by signaling through adenosine A2 receptors / A. Delikouras [et al.] // Eur J Immunol. - 2003. - Vol. 33. - P. 3127- 3135.Gaiano, N. The role of Notch in promoting glial and neural stem cell fates / N. Gaiano, G. Fishell // Annu Rev Neurosci. - 2002. - Vol. 25. - P. 471-490.Gaiano, N. The role of Notch in promoting glial and neural stem cell fates / N. Gaiano, G. Fishell // Annu Rev Neurosci. - 2002. - Vol. 25. - P. 471-490.Targeting of the chemokine receptor CCR1 suppresses development of acute and chronic cardiac allograft rejection / W. Gao [et al.] // J Clin Invest. - 2000. - Vol. 105. - P. 35-44.Targeting of the chemokine receptor CCR1 suppresses development of acute and chronic cardiac allograft rejection / W. Gao [et al.] // J Clin Invest. - 2000. - Vol. 105. - P. 35-44.Endothelial cells as targets of allograft rejection / D. Glotz [et al.] // Transplantation. - 2006. - Vol. 82, № 1. - P. 19-21.Endothelial cells as targets of allograft rejection / D. Glotz [et al.] // Transplantation. - 2006. - Vol. 82, № 1. - P. 19-21.Donor-derived IP-10 initiates development of acute allograft rejection / W.W. Hancock [et al.] // J Exp Med. - 2001. - Vol. 193. - P. 975-980.Donor-derived IP-10 initiates development of acute allograft rejection / W.W. Hancock [et al.] // J Exp Med. - 2001. - Vol. 193. - P. 975-980.Hancock, W.W. Chemokines and transplant immunobiology / W.W. Hancock // J Am Soc Nephrol. - 2002. - Vol. 13. - P. 821- 824.Hancock, W.W. Chemokines and transplant immunobiology / W.W. Hancock // J Am Soc Nephrol. - 2002. - Vol. 13. - P. 821- 824.Chemokines and their receptors as markers of allograft rejection and targets for immunosuppression / W.W. Hancock [et al.] // Curr Opin Immunol. - 2003. - Vol. 15. - P. 479-486.Chemokines and their receptors as markers of allograft rejection and targets for immunosuppression / W.W. Hancock [et al.] // Curr Opin Immunol. - 2003. - Vol. 15. - P. 479-486.Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages / L.E. Harrington [et al.] // Nat Immunol. - 2005. - Vol. 6. - P. 1123-1132.Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages / L.E. Harrington [et al.] // Nat Immunol. - 2005. - Vol. 6. - P. 1123-1132.Harrington, L.E. Expanding the effector CD4 T-cell repertoire: the Th17 lineage / L.E. Harrington, P.R. Mangan, C.T. Weaver // Curr Opin Immunol. - 2006. - Vol. 18. - P. 349-356.Harrington, L.E. Expanding the effector CD4 T-cell repertoire: the Th17 lineage / L.E. Harrington, P.R. Mangan, C.T. Weaver // Curr Opin Immunol. - 2006. - Vol. 18. - P. 349-356.Antibody, complement and accommodation in ABO-incompatible transplants / K.E. King [et al.] // Curr Opin Immunol. - 2004. - Vol. 16. - P. 545-549.Antibody, complement and accommodation in ABO-incompatible transplants / K.E. King [et al.] // Curr Opin Immunol. - 2004. - Vol. 16. - P. 545-549.The changing role of natural killer cells in solid organ rejection and tolerance / W.H. Kitchens [et al.] // Transplantation. - 2006. - Vol. 81. - P. 811-817.The changing role of natural killer cells in solid organ rejection and tolerance / W.H. Kitchens [et al.] // Transplantation. - 2006. - Vol. 81. - P. 811-817.IL-23 drives a pathogenic T cell population that induces autoimmune inflammation / C.L. Langrish [et al.] // J Exp Med. - 2005. - Vol. 201. - P. 233-240.IL-23 drives a pathogenic T cell population that induces autoimmune inflammation / C.L. Langrish [et al.] // J Exp Med. - 2005. - Vol. 201. - P. 233-240.Molecular and cellular events associated with ischemia/reperfusion injury / I. Laskowski [et al.] // Ann Transplant. - 2000. - Vol. 5. - P. 29-35.Molecular and cellular events associated with ischemia/reperfusion injury / I. Laskowski [et al.] // Ann Transplant. - 2000. - Vol. 5. - P. 29-35.Identification of the antibodies involved in B-cell crossmatch positivity in renal transplantation / S. Le Bas-Bernardet [et al.] // Transplantation. - 2003. - Vol. 75. - P. 477- 482.Identification of the antibodies involved in B-cell crossmatch positivity in renal transplantation / S. Le Bas-Bernardet [et al.] // Transplantation. - 2003. - Vol. 75. - P. 477- 482.Antigen recognition influences transendothelial migration of CD4+ T cells / F.M. Marelli-Berg [et al.] // J Immunol. - 1999. - Vol. 162. - P. 696-703.Antigen recognition influences transendothelial migration of CD4+ T cells / F.M. Marelli-Berg [et al.] // J Immunol. - 1999. - Vol. 162. - P. 696-703.Margaret, J. Dallman Immunology of graft regection /j. Margaret // Kidney Transplantation - Principles and Practice / Peter Morris, Stuart J. Knechtle. - P. 9-32.Margaret, J. Dallman Immunology of graft regection /j. Margaret // Kidney Transplantation - Principles and Practice / Peter Morris, Stuart J. Knechtle. - P. 9-32.Mellor, A.L. Immune privilege: a recurrent theme in immunoregulation / A.L. Mellor, D.H. Munn // Immunol Rev. - 2006. - Vol. 213. - P. 5-11.Mellor, A.L. Immune privilege: a recurrent theme in immunoregulation / A.L. Mellor, D.H. Munn // Immunol Rev. - 2006. - Vol. 213. - P. 5-11.Chemokines and their receptors in islet allograft rejection and as targets for tolerance induction / S. Merani [et al.] // Cell Transplant. - 2006. - Vol. 15. - P. 295-309.Chemokines and their receptors in islet allograft rejection and as targets for tolerance induction / S. Merani [et al.] // Cell Transplant. - 2006. - Vol. 15. - P. 295-309.Small molecule selectin ligand inhibition improves outcome in ischemic acute renal failure / T. Nemoto [et al.] // Kidney Int. - 2001. - Vol. 60. - P. 2205-2214.Small molecule selectin ligand inhibition improves outcome in ischemic acute renal failure / T. Nemoto [et al.] // Kidney Int. - 2001. - Vol. 60. - P. 2205-2214.Niederkorn, J.Y. The immune privilege of corneal allografts /j.Y. Niederkorn // Transplantation. - 1999. - Vol. 67. - P. 1503- 1508.Niederkorn, J.Y. The immune privilege of corneal allografts /j.Y. Niederkorn // Transplantation. - 1999. - Vol. 67. - P. 1503- 1508.A highly selective inhibitor of Rho-associated coiled-coil forming protein kinase, Y-27632, prolongs cardiac allograft survival of the BALB/c-to-C3H/He mouse model / S. Ohki [et al.] // J Heart Lung Transplant. - 2001. - Vol. 20. - P. 956-963.A highly selective inhibitor of Rho-associated coiled-coil forming protein kinase, Y-27632, prolongs cardiac allograft survival of the BALB/c-to-C3H/He mouse model / S. Ohki [et al.] // J Heart Lung Transplant. - 2001. - Vol. 20. - P. 956-963.T helper cell effector fates - who, how and where? / R.L. Reinhardt [et al.] // Curr Opin Immunol. - 2006. - Vol. 18. - P. 271- 277.T helper cell effector fates - who, how and where? / R.L. Reinhardt [et al.] // Curr Opin Immunol. - 2006. - Vol. 18. - P. 271- 277.Tubulitis after renal transplantation: demonstration of an association between CD103+ T cells, transforming growth factor beta1 expression and rejection grade / H. Robertson [et al.] // Transplantation. - 2001. - Vol. 71. - P. 306-313.Tubulitis after renal transplantation: demonstration of an association between CD103+ T cells, transforming growth factor beta1 expression and rejection grade / H. Robertson [et al.] // Transplantation. - 2001. - Vol. 71. - P. 306-313.Rossi, D. The biology of chemokines and their receptors / D. Rossi, A. Zlotnik // Annu Rev Immunol. - 2000. - Vol. 18. - P. 217-242.Rossi, D. The biology of chemokines and their receptors / D. Rossi, A. Zlotnik // Annu Rev Immunol. - 2000. - Vol. 18. - P. 217-242.Sakaguchi, S. Regulatory T cells: key controllers of immunologic self-tolerance / S. Sakaguchi // Cell. - 2000. - Vol. 101. - P. 455-458.Sakaguchi, S. Regulatory T cells: key controllers of immunologic self-tolerance / S. Sakaguchi // Cell. - 2000. - Vol. 101. - P. 455-458.Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease / S. Sakaguchi [et al.] // Immunol Rev. - 2006. - Vol. 212. - P. 8-27.Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease / S. Sakaguchi [et al.] // Immunol Rev. - 2006. - Vol. 212. - P. 8-27.Transplant accommodation in highly sensitized patients: a potential role for Bcl-xL and alloantibody / A.D. Salama [et al.] // Am J Transplant. - 2001. - Vol. 1. - P. 260-269.Transplant accommodation in highly sensitized patients: a potential role for Bcl-xL and alloantibody / A.D. Salama [et al.] // Am J Transplant. - 2001. - Vol. 1. - P. 260-269.Salama, A.D. Drug insight: rituximab in renal disease and transplantation / A.D. Salama, C.D. Pusey // Nat Clin Pract Nephrol. - 2006. - Vol. 2. - P. 221-230.Salama, A.D. Drug insight: rituximab in renal disease and transplantation / A.D. Salama, C.D. Pusey // Nat Clin Pract Nephrol. - 2006. - Vol. 2. - P. 221-230.An oral formulation for intra-cellular adhesion molecules-1 antisense oligonucleotides / S.M. Stepkowski [et al.] // Transplant Proc. - 2001. - Vol. 33, № (7-8). - P. 3271.An oral formulation for intra-cellular adhesion molecules-1 antisense oligonucleotides / S.M. Stepkowski [et al.] // Transplant Proc. - 2001. - Vol. 33, № (7-8). - P. 3271.Stepkowski, S.M. Therapeutic potential for adhesion antagonists in organ transplantation / S.M. Stepkowski // Curr Opin Organ Transplant. - 2002. - Vol. 7. - P. 366-372.Stepkowski, S.M. Therapeutic potential for adhesion antagonists in organ transplantation / S.M. Stepkowski // Curr Opin Organ Transplant. - 2002. - Vol. 7. - P. 366-372.Attenuation of renal ischemia-reperfusion injury with selectin inhibition in a rabbit model / S. Subramanian [et al.] // Am J Surg. - 1999. - Vol. 178. - P. 573-576.Attenuation of renal ischemia-reperfusion injury with selectin inhibition in a rabbit model / S. Subramanian [et al.] // Am J Surg. - 1999. - Vol. 178. - P. 573-576.Notch signaling is an important regulator of type 2 immunity / L.Tu [et al.] // J Exp Med. - 2005. - Vol. 202. - P. 1037-1042.Notch signaling is an important regulator of type 2 immunity / L.Tu [et al.] // J Exp Med. - 2005. - Vol. 202. - P. 1037-1042.NK cells can trigger allograft vasculopathy: the role of hybrid resistance in solid organ allografts / S. Uehara [et al.] // J Immunol. - 2005. - Vol. 175. - P. 3424-3430.NK cells can trigger allograft vasculopathy: the role of hybrid resistance in solid organ allografts / S. Uehara [et al.] // J Immunol. - 2005. - Vol. 175. - P. 3424-3430.TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells / M. Veldhoen [et al.] // Immunity. - 2006. - Vol. 24. - P. 179-189.TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells / M. Veldhoen [et al.] // Immunity. - 2006. - Vol. 24. - P. 179-189.Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease / M. Veldhoen [et al.] // Nat Immunol. - 2006. - Vol. 7. - P. 1151-1156.Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease / M. Veldhoen [et al.] // Nat Immunol. - 2006. - Vol. 7. - P. 1151-1156.Notch ligation by Delta1 inhibits peripheral immune responses to transplantation antigens by a CD8+ cell-dependent mechanism / K.K. Wong [et al.] // J Clin Invest. - 2003. - Vol. 112. - P. 1741-1750.Notch ligation by Delta1 inhibits peripheral immune responses to transplantation antigens by a CD8+ cell-dependent mechanism / K.K. Wong [et al.] // J Clin Invest. - 2003. - Vol. 112. - P. 1741-1750.Tubulitis in renal allograft rejection: role of transforming growth factor-beta and interleukin-15 in development and maintenance of CD103+ intraepithelial T cells / W.K. Wong [et al.] // Transplantation. - 2003. - Vol. 75. - P. 505-514.Tubulitis in renal allograft rejection: role of transforming growth factor-beta and interleukin-15 in development and maintenance of CD103+ intraepithelial T cells / W.K. Wong [et al.] // Transplantation. - 2003. - Vol. 75. - P. 505-514.Therapeutic manipulation of T cell chemotaxis in transplantation / A.C. Yopp [et al.] // Curr Opin Immunol. - 2004. - Vol. 16. - P. 571-577.Therapeutic manipulation of T cell chemotaxis in transplantation / A.C. Yopp [et al.] // Curr Opin Immunol. - 2004. - Vol. 16. - P. 571-577.

The authors declare that there are no conflicts of interest present.